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5985-28-4

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N-Isopropylnorsynephrine HCl / Deterenol Hydrochloride CAS: 23239-36-3 /Sport Nutrition/Synephrine/Methyl Synephrine HCl/Weight Control
Cas No: 5985-28-4
No Data 100 Gram Metric Ton/Day Hubei Vanz Pharm Co.,Ltd Contact Supplier
ISO Supply 5985-28-4 Stock Medicine Grade Synephrine Hydrochloride 98% Synephrine HCl Powder Synephrine
Cas No: 5985-28-4
USD $ 120.0-220.0 / Kilogram 1 Kilogram 2000 Kilogram/Quarter Xi'an Harmonious Natural Bio-Technology Co., Ltd. Contact Supplier
High Quality 99% Synephrine hydrochloride 5985-28-4 GMP Manufacturer
Cas No: 5985-28-4
USD $ 0.1-0.1 / Gram 1 Gram 100 Metric Ton/Year Xi'an Xszo Chem Co., Ltd. Contact Supplier
Synephrine hydrochloride Manufacturer/High quality/Best price/In stock
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
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Cas No: 5985-28-4
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
Medical Raw Material Loss Weight Natural Synephrine HCL Powder Price Synephrine Hydrochloride
Cas No: 5985-28-4
USD $ 245.0-262.0 / Kilogram 500 Kilogram 100000 Kilogram/Year Xi'an Quanao Biotech Co., Ltd. Contact Supplier
Synephrine hydrochloride
Cas No: 5985-28-4
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply Synephrine Hydrochloride
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No Data 1 1 Ality Chemical Corporation Contact Supplier
Pharmaceutical Intermediate CAS 5985-28-4 Synephrine Hydrochloride Synephrine HCl
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USD $ 120.0-150.0 / Kilogram 1 Kilogram 5000 Metric Ton/Month Xi'an Julong Bio-Tech Co., Ltd. Contact Supplier
Synephrine hydrochloride HIGH PURITY WITH BEST PRICE
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USD $ 90.0-100.0 / Kilogram 1 Kilogram 1000 Kilogram/Month EnBridge PharmTech Co., Ltd. Contact Supplier

5985-28-4 Usage

Description

(±)-Synephrine is an alkaloid with vasoconstrictor and metabolic activities.1,2,3 It binds to α1A-, α2A-, and α2C-adrenergic receptors (ARs; Kis = 78, 36.7, and 24.4 μM, respectively).4 (±)-Synephrine is an agonist of α1A-ARs in HEK293 cells (EC50 = 4 μM in a reporter assay) but not in CHO cells expressing α2A- or α2C-AR. It also acts as an antagonist of α1A-, α2A-, and α2C-ARs, inhibiting L-phenylephrine-induced activation of α1A-AR in HEK293 cells and activation of α2A- and α2C-ARs induced by the α2-AR agonist medetomidine in CHO cells (IC50s = 12.8, 26, and 27.3 μM, respectively, in reporter assays). (±)-Synephrine induces contractions in isolated rabbit aortic rings (EC50 = 6.2 μg/ml) and increases ligation-induced mean arterial pressure in rats when administered at a dose of 2 mg/kg per day.1,5 It induces lipolysis in isolated rat and human adipocytes when used at concentrations of 100 and 1,000 μg/ml.2 (±)-Synephrine (50 μM) increases phosphorylation of Akt and AMP-activated protein kinase (AMPK) and translocation of Glut4 to the plasma membrane, as well as increases insulin-induced glucose consumption in L6 muscle cells when used at concentrations ranging from 25 to 200 μM.3

Chemical Properties

Pale Beige Solid

Uses

A α-adrenergic receptor agonist, vasoconstrictor.
InChI:InChI=1/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5,9-12H,6H2,1H3;1H

5985-28-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[1-hydroxy-2-(methylamino)ethyl]phenol,hydrochloride

1.2 Other means of identification

Product number -
Other names (+-)-1-(4-hydroxy-phenyl)-2-methylamino-ethanol,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5985-28-4 SDS

5985-28-4Synthetic route

(+/-)-Synephrine hydrochloride
5985-28-4

(+/-)-Synephrine hydrochloride

acetyl chloride
75-36-5

acetyl chloride

2-(4-acetoxyphenyl)-2-chloro-N-methylethylammonium chloride
14593-25-0

2-(4-acetoxyphenyl)-2-chloro-N-methylethylammonium chloride

Conditions
ConditionsYield
In acetic acid at 10 - 30℃; for 12h;83.6%
hydrogenchloride
7647-01-0

hydrogenchloride

(+/-)-Synephrine hydrochloride
5985-28-4

(+/-)-Synephrine hydrochloride

acetic acid
64-19-7

acetic acid

acetyl chloride
75-36-5

acetyl chloride

4-acetoxy-1-<1-chloro-2-methylamino-ethyl>-benzene hydrochloride

4-acetoxy-1-<1-chloro-2-methylamino-ethyl>-benzene hydrochloride

cucurbit[6]uril decahydrate

cucurbit[6]uril decahydrate

(+/-)-Synephrine hydrochloride
5985-28-4

(+/-)-Synephrine hydrochloride

C36H36N24O12*2C9H13NO2*14H2O*2Cl(1-)*2H(1+)

C36H36N24O12*2C9H13NO2*14H2O*2Cl(1-)*2H(1+)

Conditions
ConditionsYield
Stage #1: cucurbit[6]uril decahydrate With magnesium(II) chloride hexahydrate; water Heating;
Stage #2: (+/-)-Synephrine hydrochloride for 48h;
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