145965-14-6

Basic information

• Product Name: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)
• Synonyms: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI);(4-Bromonaphthalen-1-yl)boronic acid;4-Bromo-1-naphthaleneboronic acid;4-Bromonaphthalene-1-boronic acid;4-broMo-1-naphthalenylboronic acid;1-BroMonaphthalene-4-boronic acid;B-(4-bromo-1-naphthalenyl)boronic acid;4-Bromo-1-naphthaleneboronic Acid (contains varying amounts of Anhydride)
• CAS NO: 145965-14-6
• Molecular Formula: C10H8BBrO2
• Molecular Weight: 250.88432
• Product Categories: BORONICACID
• Mol File: 145965-14-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 230-260 °C
• Boiling Point: 421.7±47.0 °C(Predicted)
• Appearance: White to pale brown/Solid
• Density: 1.62±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.16±0.30(Predicted)
• CAS DataBase Reference: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)(145965-14-6)
• EPA Substance Registry System: Boronic acid, (4-bromo-1-naphthalenyl)- (9CI)(145965-14-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 145965-14-6(Hazardous Substances Data)

Usage

General Description

Boronic acid, (4-bromo-1-naphthalenyl)- (9CI) is a chemical compound that belongs to the class of boronic acids. It is a derivative of naphthalene, a polycyclic aromatic hydrocarbon. Boronic acids are widely used in organic synthesis as reagents in Suzuki-Miyaura cross-coupling reactions, which are important processes in the formation of carbon-carbon bonds. This particular boronic acid derivative containing a bromo-substituent on the naphthalene ring may have specific applications in organic synthesis and materials science due to its unique reactivity and structural features. Its properties and reactivity make it a potentially valuable building block for the synthesis of organic compounds and materials with specific functions and properties.

Upstream product

• 121-43-7 Trimethyl borate 
• 83-53-4 1,4-dibromonaphthalene 
• 5419-55-6 Triisopropyl borate 
• 91-20-3 naphthalene 

Downstream Products

• 131409-18-2 5-bromo-7H-benzo[c]carbazole 
• 1238872-57-5 (4-(naphthalen-1-yl(phenyl)amino)naphthalen-1-yl)boronic acid 
• 4236-05-9 4-bromo-1-nitronaphthalene 
• 1800228-86-7 2-(4-bromonaphthalene-1-yl)-4,6-diphenyl-1,3,5-triazine 

Relevant articles and documents

Discovery of a flexible triazolylbutanoic acid as a highly potent uric acid transporter 1 (URAT1) inhibitor

In order to systematically explore and understand the structure-activity relationship (SAR) of a lesinurad-based hit (1c) derived from the replacement of the S atom in lesinurad with CH2, 18 compounds (1a-1r) were designed, synthesized and subjected to in vitro URAT1 inhibitory assay. The SAR exploration led to the discovery of a highly potent flexible URAT1 inhibitor, 1q, which was 31-fold more potent than parent lesinurad (IC50 = 0.23 μM against human URAT1 for 1q vs. 7.18 μM for lesinurad). The present study discovered a flexible molecular scaffold, as represented by 1q, which might serve as a promising prototype scaffold for further development of potent URAT1 inhibitors, and also demonstrated that the S atom in lesinurad was not indispensable for its URAT1 inhibitory activity.

Organic light-emitting device including diamine compound and diamine compound

The present invention provide a diamine compound and an organic light-emitting device including the same. The organic light-emitting device includes: a first electrode; a second electrode; and an organic layer between the first electrode and the second electrode and comprising an emission layer, the organic layer including a diamine compound represented by one selected from Formulae 1-1 to 1-8.

Composite taken as URAT 1 inhibitor

The invention provides a series of composite with a formula (I), wherein n is selected from 1, 2 or 3, X is selected from O or S, Q is selected from C or N, and R is selected from H, halogen or -C1-6.The composite can be used as the URAT 1 inhibitor and can be used for treating hyperuricemia and gout.