146-94-1 Usage
General Description
2-Azaadenosine is a chemical compound that belongs to the family of purine analogs. It is a modified form of adenosine, containing a nitrogen atom in place of the carbon atom in the purine ring. This alteration gives 2-azaadenosine unique biological properties, making it a potential therapeutic agent for various diseases. It has been studied for its anti-inflammatory and anti-cancer properties, as well as its potential to modulate immune responses. Additionally, 2-azaadenosine has been found to inhibit the activity of adenosine deaminase, an enzyme involved in purine metabolism, making it a valuable research tool in studies related to adenosine signaling pathways. Overall, 2-azaadenosine shows promise for future development as a pharmacological agent, with potential applications in various medical fields.
Check Digit Verification of cas no
The CAS Registry Mumber 146-94-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146-94:
(5*1)+(4*4)+(3*6)+(2*9)+(1*4)=61
61 % 10 = 1
So 146-94-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N6O4/c10-7-4-8(13-14-12-7)15(2-11-4)9-6(18)5(17)3(1-16)19-9/h2-3,5-6,9,16-18H,1H2,(H2,10,12,13)
146-94-1Relevant articles and documents
Synthesis of 4-substituted imidazo[4,5-d][1,2,3]triazine (2- azapurine)nucleosides
Krawczyk, Steven,Migawa, Michael T.,Drach, John C.,Townsend, Leroy B.
, p. 39 - 68 (2000)
Several methods for functionalization of the 4-position of imidazo[4,5- d][1,2,3]triazin-4-one were investigated. These investigations were successful and led to the preparation of 4-amino, 4-triazol-1-yl, 4-methoxy, 4-methylthio, 4-methylamino, 4-thio, 4-nitrobenzyl, and 4-unsubstituted 9- (β-D-ribofuranosyl)-imidazo-[4,5-d][1,2,3]triazine (2-azapurine ribosides). The 4-unsubstituted compound (19) was slightly active against HCMV in plaque and yield reduction experiments and was not cytotoxic at 100 ♂m. The methylamino (15), hydrazino (16), and p-nitrobenzylthio (20) were inactive against HCMV but slightly cytotoxic. The thiomethyl-substituted analog (21) was the most active with activity comparable to ganciclovir but with greater cytotoxicity. We conclude that even though none of the tested compounds had antiviral activity superior to ganciclovir, the new synthetic methods will provide a route to more interesting compounds.
