36519-17-2Relevant academic research and scientific papers
Purine nucleoside analogues for treating flaviviridae including hepatitis C
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Page/Page column 82, (2016/02/05)
This invention is directed to a method for treating a host, especially a human, infected with hepatitis C, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-HCV biologically active pentofuranonucleoside whe
Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes
Ikeuchi, Kazutada,Fujii, Ryosuke,Sugiyama, Shimpei,Asakawa, Tomohiro,Inai, Makoto,Hamashima, Yoshitaka,Choi, Jae-Hoon,Suzuki, Tomohiro,Kawagishi, Hirokazu,Kan, Toshiyuki
supporting information, p. 3813 - 3815 (2014/06/09)
We describe a practical, large-scale synthesis of the "fairy- ring" plant-growth regulator 2-azahypoxanthine (AHX), and its biologically active hydroxyl metabolite (AOH) and riboside derivative (AHXr). AHXr, a biosynthetic intermediate, was synthesized from inosine via a biomimetic route. Biotinylated derivatives of AHX and AHXr were also synthesized as probes for mechanistic studies. This journal is the Partner Organisations 2014.
Synthesis and biophysical and biological properties of oligonucleotides containing 2-aza-2'-deoxyinosine
Acedo,De Clercq,Eritja
, p. 6262 - 6269 (2007/10/03)
The preparation of oligonucleotides containing 2-aza-2'-deoxyinosine is described. Protection of the 2-azahypoxanthine moiety with the photolabile 2-nitrobenzyl group enabled us to obtain the phosphoramidite derivative and oligonucleotides containing protected 2-aza-2'-deoxyinosine. After purification, photolysis of the oligonucleotides containing the protected analogue provided the desired oligonucleotides in good yields. Melting curves of duplexes containing 2-azahypoxanthine paired with the four natural bases at pH 6 and pH 8 proved that 2-azahypoxanthine base pairs were less stable than perfectly matched duplexes but showed little variation among different bases.
