1460-38-4

Basic information

• Product Name: 2-OXO-CYCLOPENTANEACETIC ACID
• Synonyms: 2-OXO-CYCLOPENTANEACETIC ACID;2-Oxocyclopentylacetic acid, 97%;2-(2-oxocyclopentyl)acetic acid;2-Oxocyclopentaneacetic acid 97%;Cyclopentaneacetic acid, 2-oxo-
• CAS NO: 1460-38-4
• Molecular Formula: C7H10O3
• Molecular Weight: 142.15
• Product Categories: C7;Carbonyl Compounds;Carboxylic Acids
• Mol File: 1460-38-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 47-51 °C(lit.)
• Boiling Point: 316.5°Cat760mmHg
• Flash Point: 230 °F
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 8.69E-05mmHg at 25°C
• Refractive Index: 1.492
• PKA: 4.36±0.10(Predicted)
• CAS DataBase Reference: 2-OXO-CYCLOPENTANEACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-OXO-CYCLOPENTANEACETIC ACID(1460-38-4)
• EPA Substance Registry System: 2-OXO-CYCLOPENTANEACETIC ACID(1460-38-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 1460-38-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 1157, 1990 DOI: 10.1016/S0040-4039(00)88751-1

InChI:InChI=1/C7H10O3/c8-6-3-1-2-5(6)4-7(9)10/h5H,1-4H2,(H,9,10)

Upstream product

• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 96-32-2 bromoacetic acid methyl ester 
• 141-28-6 diethyl adipate 
• 40702-70-3 ethyl 2-oxo-cyclopentanecarboxylate potassium salt 
• 20826-94-2 ethyl (2-oxocyclopentyl)acetate 
• 7647-01-0 hydrogenchloride 
• 41301-66-0 ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclopentanecarboxylate 
• 844874-18-6 exo-2,3-epoxynorbornane 
• 105-39-5 chloroacetic acid ethyl ester 
• 100796-98-3 {2-[(2,4-Dinitro-phenyl)-hydrazono]-cyclopentyl}-acetic acid 
• 91783-90-3 Cyclopentanon-⁽²⁾-oxalsaeure-⁽¹⁾ 

Downstream Products

• 102472-53-7 (+/-)-cis-1-(toluene-4-sulfonyloxy)-2-[2-(toluene-4-sulfonyloxy)-ethyl]-cyclopentane 
• 109654-84-4 2-methyl-7,8,9,10-tetrahydro-5H-benzo[b]cyclopent[d]azepin-6-one 

Relevant articles and documents

Acyl acid derivative and preparation method and medical application thereof

The invention relates to an acyl acid derivative as well as a preparation method and medical application thereof. Specifically, the invention relates to a compound represented by a general formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutical composition containing the same, and the invention also relates to a use thereof as an active ingredient in the prevention and/or treatment of muscle atrophy-related diseases, including myogenic muscle atrophy, disuse muscle atrophy, senile muscle atrophy, neurogenic muscle atrophy, and a use in the prevention and/or treatment of obesity, fatty liver, cardiovascular and cerebrovascular diseases, metabolic diseases, and anti-aging, wherein the definition of each group in the general formula (I) is the same as the definition in the specification.

NOVEL COMPOUNDS

Disclosed are novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

The present invention relates to certain substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 receptor-associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.