41301-66-0

Basic information

• Product Name: ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE
• Synonyms: ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE;1-ETHOXYCARBONYLMETHYL-2-OXO-CYCLOPENTANECARBOXYLIC ACID ETHYL ESTER;2-Carbethoxy-2-(carbethoxymethyl)-1-cyclopentanone;ethyl 1-(2-ethoxy-2-oxoethyl)-2-oxocyclopentanecarboxylate(WXC09114)
• CAS NO: 41301-66-0
• Molecular Formula: C₁₂H₁₈O₅
• Molecular Weight: 242.27
• Mol File: 41301-66-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE(41301-66-0)
• EPA Substance Registry System: ETHYL 1-(2-ETHOXY-2-OXOETHYL)-2-OXOCYCLOPENTANECARBOXYLATE(41301-66-0)

Safety Data

• Hazardous Substances Data: 41301-66-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 316, 1973 DOI: 10.1055/s-1973-22208

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 105-39-5 chloroacetic acid ethyl ester 
• 141-28-6 diethyl adipate 
• 105-36-2 ethyl bromoacetate 
• 40702-70-3 ethyl 2-oxo-cyclopentanecarboxylate potassium salt 

Downstream Products

• 91524-79-7 ethyl<3-(4-methylphenylsulfonyl-hydrazino)-2-ethoxycarbonylmethyl>-cyclopentane carboxylate 
• 104115-44-8 (2-oxocyclopent)acetic acid 
• 1206125-32-7 ethyl 7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-3-(2-ethoxy-2-oxoethyl)-1,2,3,4-tetrahydrocyclopenta[b]indole-3-carboxylate 
• 1206123-97-8 (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid, L-arginine salt 
• 1206123-37-6 [(3R)-7-{[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy}-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid 
• 1206124-34-6 (R/S)-ethyl 2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetate 

Relevant articles and documents

C-8-quaternary prostaglandin analogs

A simple and convenient synthesis of the title compounds is presented.

PROCESSES FOR THE PREPARATION OF (R)-2-(7-(4-CYCLOPENTYL-3-(TRIFLUOROMETHYL)BENZYLOXY)-1,2,3,4-TETRAHYDROCYCLOPENTA[B]INDOL-3-YL)ACETIC ACID AND SALTS THEREOF

The present invention relates to processes and intermediates useful in the preparation of of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of Formula (Ia) and salts thereof, an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development and atherosclerosis).

TETRAHYDROCYCLOPENTA[B]INDOL-3-YL CARBOXYLIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS

The present invention relates to certain (1,2,4-oxadiazol-3-yl)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, acne, microbial infections or diseases and viral infections or diseases.