146004-98-0

Basic information

• Product Name: 16-(Benzyloxy)-16-Oxohexadecanoic Acid
• Synonyms: 16-(Benzyloxy)-16-Oxohexadecanoic Acid;Hexadecanedioic acid, 1-(phenylmethyl) ester
• CAS NO: 146004-98-0
• Molecular Formula: C₂₃H₃₆O₄
• Molecular Weight: 376.52954
• Mol File: 146004-98-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 505.8±23.0 °C(Predicted)
• Appearance: /
• Density: 1.023±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.78±0.10(Predicted)
• CAS DataBase Reference: 16-(Benzyloxy)-16-Oxohexadecanoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 16-(Benzyloxy)-16-Oxohexadecanoic Acid(146004-98-0)
• EPA Substance Registry System: 16-(Benzyloxy)-16-Oxohexadecanoic Acid(146004-98-0)

Safety Data

• Hazardous Substances Data: 146004-98-0(Hazardous Substances Data)

Usage

General Description

16-(Benzyloxy)-16-Oxohexadecanoic Acid, also known as 16-BODOHA, is a synthetic compound that belongs to the class of fatty acids. It is a derivative of palmitic acid and contains a benzyl group attached to the hydroxyl group at the 16th carbon, as well as a ketone group at the 16th carbon. This chemical compound is commonly used in the field of organic chemistry and drug development as a building block for the synthesis of various bioactive molecules. It has been studied for its potential pharmaceutical applications, including as an anti-inflammatory and anti-cancer agent. Overall, 16-(Benzyloxy)-16-Oxohexadecanoic Acid is a versatile compound with diverse potential uses in medicinal chemistry and chemical synthesis.

Upstream product

• 505-54-4 thapsic acid 
• 100-44-7 benzyl chloride 
• 1034470-47-7 hexadecanedioic acid-anhydride 
• 100-51-6 benzyl alcohol 
• 1460-18-0 pentadecanedioic acid 
• 104-57-4 benzyl formate 
• 100-39-0 benzyl bromide 

Downstream Products

• 949588-04-9 benzylhexadecandioyl-L-Glu-OBn 
• 949588-05-0 benzylhexadecandioyl-L-Glu(OSu)-OBn 
• 949588-03-8 benzyl 16-((2,5-dioxopyrrolidin-1-yl)oxy)-16-oxohexadecanoate 
• 362707-53-7 1,14-tetradecanedicarboxylic acid monochloride monobenzyl ester 
• 1292292-57-9 C₅₁H₈₁NO₈ 
• 1292292-52-4 C₅₂H₈₄NO₈⁽¹⁺⁾*I^(1-) 

Relevant articles and documents

Method for preparing long aliphatic chain diacid derivative and application of long aliphatic chain diacid derivative

The invention provides a method for preparing a long aliphatic chain diacid derivative. The method comprises the following steps of: (1) carrying out a cyclization reaction on long aliphatic chain diacid, the long aliphatic chain diacid having a structure as shown in a formula (A); (2) reacting the long aliphatic chain diacid cyclization product with benzyl alcohol to obtain long aliphatic chain diacid monobenzyl ester; (3) carrying out an esterification reaction on the long aliphatic chain diacid monobenzyl ester and N-hydroxysuccinimide so as to obtain long aliphatic chain diacid succinimide benzyl ester; (4) carrying out a nucleophilic addition amidation reaction on the long aliphatic chain diacid succinimide benzyl ester and a compound as shown in a formula (B) to obtain a compound as shown in a formula (C); (5) carrying out an esterification reaction on the compound as shown in the formula (C) and N-hydroxysuccinimide again so as to obtain a compound as shown in a formula (D); and (6) carrying out a debenzylation reaction on the compound shown in the formula (D) so as to obtain a compound shown in a formula (E).

Preparation method of long-chain diacid mono-benzyl ester compound

The invention relates to the field of chemical organic synthesis, in particular to a preparation method of a long-chain diacid mono-benzyl ester compound. The preparation method comprises the following steps: taking long-chain dicarboxylic acid as an initial raw material, firstly preparing a dibenzyl ester compound, and then carrying out lithium hydroxide mono-hydrolysis to obtain the long-chain diacid mono-benzyl ester compound. The provided preparation method overcomes the defects of long steps, complex method, poor selectivity and low yield of a traditional process. Besides, the prepared long-chain diacid mono-benzyl ester compound is used as an important synthesis intermediate, has an active reaction group and can be used for preparing a series of long-chain compounds.

Improved Syntheses of Benzyl Hydraphile Synthetic Cation-Conducting Channels

The tris(macrocycle)s that function in bilayer membranes as ion channels have recently shown versatile new applications such as antibiotic synergists and as agents for direct injection chemotherapy. This report records the development of new and versatile approaches to these molecules that produce significantly better overall yields for a group of previously reported hydraphiles having spacer chains ranging from octylene to hexadecylene.