1460257-57-1

Basic information

• Product Name: 1-(4-chloro-benzoyl)-2-oxolycorine
• CAS NO: 1460257-57-1
• Molecular Weight: 423.853
• Mol File: 1460257-57-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-chloro-benzoyl)-2-oxolycorine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-chloro-benzoyl)-2-oxolycorine(1460257-57-1)
• EPA Substance Registry System: 1-(4-chloro-benzoyl)-2-oxolycorine(1460257-57-1)

Safety Data

• Hazardous Substances Data: 1460257-57-1(Hazardous Substances Data)

Upstream product

• 2492-05-9 1,2-diacetoxylycorine 
• 122-01-0 4-chloro-benzoyl chloride 
• 6403-51-6 (1S,3a1S,12bS)-2-oxo-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-1-yl acetate 
• 476-28-8 lycorine 
• 7344-73-2 1-O-acetyllycorine 

Relevant articles and documents

Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

Dengue is a systemic viral infection that is transmitted to humans by Aedes mosquitoes. No vaccines or specific therapeutics are currently available for dengue. Lycorine, which is a natural plant alkaloid, has been shown to possess antiviral activities against flaviviruses. In this study, a series of novel lycorine derivatives were synthesized and assayed for their inhibition of dengue virus (DENV) in cell cultures. Among the lycorine analogues, 1-acetyllycorine exhibited the most potent anti-DENV activity (EC50=0.4 μM) with a reduced cytotoxicity (CC50>300 μM), which resulted in a selectivity index (CC50/EC50) of more than 750. The ketones 1-acetyl-2-oxolycorine (EC50=1.8 μM) and 2-oxolycorine (EC50=0.5 μM) also exhibited excellent antiviral activities with low cytotoxicity. Structure-activity relationships for the lycorine derivatives against DENV are discussed. A three-dimensional quantitative structure-activity relationship model was established by using a comparative molecular-field analysis protocol in order to rationalize the experimental results. Further modifications of the hydroxy group at the C1 position with retention of a ketone at the C2 position could potentially lead to inhibitors with improved overall properties. Alkaloids that bite back: Dengue is a systemic viral infection that is transmitted to humans by Aedes mosquitoes. Currently, vaccines or specific therapeutics are not available. Lycorine, which is a natural alkaloid, has reportedly demonstrated biological activity against dengue virus (DENV). A series of lycorine derivatives and their anti-DENV activities are reported herein.