6403-51-6

Basic information

• Product Name: 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide
• CAS NO: 6403-51-6
• Molecular Formula: C₁₉H₂₄N₂O₃
• Molecular Weight: 328.4055
• Mol File: 6403-51-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 495°C at 760 mmHg
• Flash Point: 253.2°C
• Density: 1.103g/cm³
• Vapor Pressure: 6.14E-10mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide(6403-51-6)
• EPA Substance Registry System: 3,5-dipropoxy-N-(pyridin-3-ylmethyl)benzamide(6403-51-6)

Safety Data

• Hazardous Substances Data: 6403-51-6(Hazardous Substances Data)

Upstream product

• 7344-73-2 1-O-acetyllycorine 
• 476-28-8 lycorine 
• 2492-05-9 1,2-diacetoxylycorine 
• 69787-57-1 (1S,2S,3a¹S,12bS)-2-chloro-2,3a¹,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]-phenanthridin-1-yl acetate 
• 108-24-7 acetic anhydride 
• 2188-68-3 (1S,2S,12bS,12cS)-1,2-diol-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine hydrochloride 

Downstream Products

• 1210819-43-4 1-benzoyl-2-oxolycorine 
• 1460257-57-1 1-(4-chloro-benzoyl)-2-oxolycorine 
• 1460257-58-2 1-(4-methoxyl-benzoyl)-2-oxolycorine 

Relevant articles and documents

Synthesis and antiviral activity of lycorine derivatives

There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in?vitro. Derivatives 7c-m with the phenoxyacyl gro

Lycorine derivatives and application thereof to pesticides

The invention relates to lycorine compounds with structures from (1-1) to (1-20) represented in the description as well as an application of the lycorine compounds to pesticides. When the lycorine compounds are used as novel insecticides and bactericides, part of the compounds have toxic activity on armyworms, mosquito larvae, cotton bollworms and ostrinia nubilalis and have higher inhibition ratio on wheat scab, potato late blight, rape sclerotinia rot and cucumber gray mold than that of a lycorine matrix.

Anti-dengue-virus activity and structure-activity relationship studies of lycorine derivatives

Dengue is a systemic viral infection that is transmitted to humans by Aedes mosquitoes. No vaccines or specific therapeutics are currently available for dengue. Lycorine, which is a natural plant alkaloid, has been shown to possess antiviral activities against flaviviruses. In this study, a series of novel lycorine derivatives were synthesized and assayed for their inhibition of dengue virus (DENV) in cell cultures. Among the lycorine analogues, 1-acetyllycorine exhibited the most potent anti-DENV activity (EC50=0.4 μM) with a reduced cytotoxicity (CC50>300 μM), which resulted in a selectivity index (CC50/EC50) of more than 750. The ketones 1-acetyl-2-oxolycorine (EC50=1.8 μM) and 2-oxolycorine (EC50=0.5 μM) also exhibited excellent antiviral activities with low cytotoxicity. Structure-activity relationships for the lycorine derivatives against DENV are discussed. A three-dimensional quantitative structure-activity relationship model was established by using a comparative molecular-field analysis protocol in order to rationalize the experimental results. Further modifications of the hydroxy group at the C1 position with retention of a ketone at the C2 position could potentially lead to inhibitors with improved overall properties. Alkaloids that bite back: Dengue is a systemic viral infection that is transmitted to humans by Aedes mosquitoes. Currently, vaccines or specific therapeutics are not available. Lycorine, which is a natural alkaloid, has reportedly demonstrated biological activity against dengue virus (DENV). A series of lycorine derivatives and their anti-DENV activities are reported herein.