146135-21-9

Basic information

• Product Name: 1-(3-Fluorophenyl)-2,5-diMethylpyrrole
• Synonyms: 1-(3-Fluorophenyl)-2,5-diMethylpyrrole
• CAS NO: 146135-21-9
• Molecular Formula: C₁₂H₁₂FN
• Molecular Weight: 189.2287832
• Mol File: 146135-21-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 272.1 °C at 760 mmHg
• Flash Point: 118.3 °C
• Appearance: /
• Density: 1.04 g/cm³
• CAS DataBase Reference: 1-(3-Fluorophenyl)-2,5-diMethylpyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Fluorophenyl)-2,5-diMethylpyrrole(146135-21-9)
• EPA Substance Registry System: 1-(3-Fluorophenyl)-2,5-diMethylpyrrole(146135-21-9)

Safety Data

• Hazardous Substances Data: 146135-21-9(Hazardous Substances Data)

Usage

General Description

1-(3-Fluorophenyl)-2,5-diMethylpyrrole, also known as FPP, is a chemical compound with a molecular formula C13H12FN. It is a derivative of pyrrole and contains a 3-fluorophenyl group and two methyl groups attached to the pyrrole ring. FPP is an aromatic heterocyclic compound and is commonly used as a building block in organic synthesis. It possesses potential pharmaceutical properties and is of interest in the development of new drugs. FPP has also been studied for its potential applications in materials science and as a ligand in coordination chemistry. Overall, FPP is a versatile chemical with diverse potential uses in the field of chemistry and pharmaceutical research.

Upstream product

• 625-86-5 2,5-dimethylfuran 
• 372-19-0 meta-fluoroaniline 
• 74-86-2 acetylene 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 110-13-4 2,5-hexanedione 

Downstream Products

• 890241-69-7 C₁₈H₁₈FN₃OS 
• 428497-01-2 C₁₃H₁₂FNO 

Relevant articles and documents

Magnetic solid sulfonic acid-enabled direct catalytic production of biomass-derived N-substituted pyrroles

Five-membered nitrogen heterocyclic pyrroles have extremely high physiological activity and are widely used in medicine, agriculture, materials chemistry, industry, and supramolecular chemistry. Developing a mild and eco-friendly way to synthesize functionalized pyrroles from biologically derived materials is desirable. In this study, biomass-derived 2,5-dimethylfuran can react with a series of aromatic amines to synthesize 2,5-dimethyl-N-arylpyrroles through acid-enabled ring-opening and Paal-Knorr condensation in one pot. Among the tested acid catalytic materials, a new magnetic biocarbon-based sulfonic acid solid catalyst (WK-SO3H) showed excellent catalytic performance in the synthesis of N-substituted pyrroles (up to ca. 90% yield) and was easy to separate and recover by an external magnetic field. The ring-opening of furan proved to be the rate-determining step of the above one-pot multi-step conversion process, and 2,5-hexanedione is a key intermediate for the cascade reaction, while the addition of water could significantly enhance the above-mentioned ring-opening reaction. Furthermore, multiple characterization methods (e.g., FT-IR, TGA, XRD, NH3-TPD, and XPS) confirmed that WK-SO3H has good stability in the aqueous reaction system.

Indium-mediated one-pot pyrrole synthesis from nitrobenzenes and 1,4-diketones

One-pot reduction-triggered heterocyclizations of nitrobenzene derivatives with 1,4-diketones were investigated. In the presence of indium/AcOH in toluene at 80 C, reaction of nitrobenzenes with 2,5-hexadione produced moderate to excellent yields (40-98%)