428497-01-2 Usage
Uses
Used in Pharmaceutical and Chemical Synthesis:
1-(3-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde is used as a building block for the synthesis of various organic molecules with potential biological activity. Its unique structure and reactivity allow for the creation of compounds that can be further explored for their therapeutic properties.
Used in Chemical Analysis and Imaging Studies:
Due to its fluorescent properties, 1-(3-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde is used in chemical analysis and imaging studies. Its ability to emit fluorescence can be utilized for detecting and visualizing specific molecules or structures in various research applications.
Used in Organic Chemistry and Biochemistry Research:
1-(3-Fluoro-phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde may also serve as a research reagent in the fields of organic chemistry and biochemistry. Its distinctive characteristics can aid scientists in understanding various chemical reactions and biological processes, potentially leading to new discoveries and advancements in these disciplines.
Check Digit Verification of cas no
The CAS Registry Mumber 428497-01-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,8,4,9 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 428497-01:
(8*4)+(7*2)+(6*8)+(5*4)+(4*9)+(3*7)+(2*0)+(1*1)=172
172 % 10 = 2
So 428497-01-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H12FNO/c1-9-6-11(8-16)10(2)15(9)13-5-3-4-12(14)7-13/h3-8H,1-2H3
428497-01-2Relevant academic research and scientific papers
Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3- alkyl-2-(alkylimino)thiazolidin-4-one chemotype
Urbano, Mariangela,Guerrero, Miguel,Velaparthi, Subash,Crisp, Melissa,Chase, Peter,Hodder, Peter,Schaeffer, Marie-Therese,Brown, Steven,Rosen, Hugh,Roberts, Edward
, p. 6739 - 6745 (2011/12/05)
High affinity and selective S1P4 receptor (S1P4-R) small molecule agonists may be important proof-of-principle tools used to clarify the receptor biological function and effects to assess the therapeutic potential of the S1P4-R in diverse disease areas including treatment of viral infections and thrombocytopenia. A high-throughput screening campaign of the Molecular Libraries-Small Molecule Repository was carried out by our laboratories and identified (2Z,5Z)-5-((1-(2-fluorophenyl)-2,5-dimethyl-1H- pyrrol-3-yl)methylene)-3-methyl-2-(methylimino) thiazolidin-4-one as a promising S1P4-R agonist hit distinct from literature S1P4-R modulators. Rational chemical modifications of the hit allowed the identification of a promising lead molecule with low nanomolar S1P4-R agonist activity and exquisite selectivity over the other S1P 1-3,5-Rs family members. The lead molecule herein disclosed constitutes a valuable pharmacological tool to explore the effects of the S1P4-R signaling cascade and elucidate the molecular basis of the receptor function.
