146176-64-9Relevant academic research and scientific papers
S-Aryl cysteine S,S-dioxides as inhibitors of mammalian kynureninase
Drysdale, Martin J.,Reinhard, John F.
, p. 133 - 138 (2007/10/03)
A series of 2-amino-S-aryl cysteine S,S-dioxides have been synthesised and shown to inhibit kynureninase an important enzyme in the biosynthesis of the known excitotoxic moiety quinolinic acid. The most potent of these, 2-amino-5-methyl-S-phenyl cysteine S,S-dioxide 6d, inhibits interferon-γ induced synthesis of quinolinic acid in human macrophages.
