14618-93-0Relevant academic research and scientific papers
Synthesis of α,β-Unsaturated Ketones and α,β-Epoxyketones via Hydroboration of 1-Halo-3-alken-1-ynes
Zweifel, George,Shoup, Timothy M.
, p. 130 - 131 (2007/10/02)
The preparation of α,β-unsaturated ketones and α,β-epoxyketones from readily accessible 1-haloenynes are described.The procedures involve the regio- and stereoselective hydroboration of 1-haloenynes, base-mediated rearrangement of the resultant 1-halodienylboranes, and oxidative work-up under appropriate conditions of the dienylboranes formed.
172. β-Cleavage of Bis(homoallylic) Potassium Alkoxides. Two-Step Preparation of Propenyl Ketones from Carboxylic Esters. Synthesis of ar-Turmerone, α-Damascone, β-Damascone, and β-Damascenone
Snowden, Roger L.,Linder, Simon M.,Muller, Bernard L.,Schulte, Karl H.
, p. 1858 - 1878 (2007/10/02)
The transformation of 36 bis(homoallylic) alcohols VII to alkenones IX and X via β-cleavage of their potassium alkoxides VIIa in HMPA has been investigated (cf.Scheme 2).These studies have established an order of β-cleavage for 2-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1,1-dimethyl-2-propenyl, and benzyl groups in alkoxides 49a-56a and have allowed a comparison between the β-cleavage reaction and the oxy-Cope rearrangement in alkoxides 74a-83a.As illustrative synthetic applications, a two-step preparation of propenyl ketones 15-42 from carboxylic esters is described, together with syntheses of ar-turmerone (48), α-damascone ((E)-71), β-damascone ((E)-109), and β-damascenone ((E)-111).
