146204-41-3

Upstream product

• 100-01-6 4-nitro-aniline 
• 583-05-1 1-phenylpentane-1,4-dione 
• 123-76-2 levulinic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 146204-61-7 2-Methyl-1-(4-nitro-phenyl)-5-phenyl-3-pyrrolidin-1-ylmethyl-1H-pyrrole 
• 146204-51-5 1-Methyl-4-[2-methyl-1-(4-nitro-phenyl)-5-phenyl-1H-pyrrol-3-ylmethyl]-piperazine 

Relevant academic research and scientific papers

A fluorescent target-guided Paal-Knorr reaction

It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a ‘target-guided synthesis’ concept with Paal-Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).

Synthesis of two distinct pyrrole moiety-containing arenes from nitroanilines using Paal-Knorr followed by an indium-mediated reaction

Synthesis of arenes substituted with two differently substituted-pyrrole moieties was investigated. A Paal-Knorr condensation reaction of nitroanilines with 1,4-diketone to nitrophenyl-1H-pyrroles followed by an indium-mediated reduction-triggered coupling reaction with another kind of 1,4-diketone resulted in two distinct pyrrole-containing arenes, variously substituted 1-((1H-pyrrol-1-yl)phenyl)-1H-pyrroles, in reasonable yield.

Studies on anti-Candida agents with a pyrrole moiety. Synthesis and microbiological activity of some 3-aminomethyl-1,5-diaryl-2-methyl-pyrrole derivatives

The synthesis and anti-Candida activity of some 3-aminomethyl-1,5-diaryl-2-methyl-pyrrole derivatives are reported. Some derivatives show a rather strong anti-Candida activity. On the basis of experimental results, microbiological activity of 1,5-diarylpy