146324-43-8

Basic information

• Product Name: (S)-2-FLUOROBENZHYDROL
• Synonyms: (1S)-(2-Fluorophenyl)(phenyl)methanol;Benzenemethanol,2-fluoro-a-phenyl-, (aS)-
• CAS NO: 146324-43-8
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.2269
• Mol File: 146324-43-8.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 312.3°Cat760mmHg
• Flash Point: 172.6°C
• Appearance: /
• Density: 1.18g/cm³
• CAS DataBase Reference: (S)-2-FLUOROBENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-FLUOROBENZHYDROL(146324-43-8)
• EPA Substance Registry System: (S)-2-FLUOROBENZHYDROL(146324-43-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 146324-43-8(Hazardous Substances Data)

Usage

General Description

(S)-2-Fluorobenzhydrol is an organic chemical compound with the molecular formula C7H7FO. It is a colorless liquid with a molecular weight of 126.13 g/mol. (S)-2-FLUOROBENZHYDROL is commonly used in the synthesis of pharmaceuticals and other organic compounds. It can also be utilized as a reagent in various chemical reactions, particularly in the field of organic chemistry. (S)-2-Fluorobenzhydrol is known for its ability to participate in chemical reactions, making it a versatile and valuable compound in the field of organic synthesis. Additionally, it is important to handle this compound with care, as it may pose health and safety hazards if not properly handled.

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 98-80-6 phenylboronic acid 
• 393-52-2 2-Fluorobenzoyl chloride 
• 71-43-2 benzene 
• 3262-89-3 triphenylboroxine 
• 3794-15-8 1-benzyl-2-fluorobenzene 
• 362-54-9 2-fluorobenzhydrol 
• 342-24-5 o-fluorobenzophenone 
• 1078-58-6 diphenylzinc 
• 16635-23-7 phenyltriisopropoxytitanium(IV) 

Relevant articles and documents

Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes

The use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho-substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)-neobenodine.

Method for synthesizing chiral secondary alcohol compound

The invention discloses a method for synthesizing a chiral secondary alcohol compound. The method comprises the following step of: reacting a ketone compound in an aprotic organic solvent at room temperature and inert gas atmosphere under the action of a chiral cobalt catalyst and an activating agent by taking a combination of bis(pinacolato)diboron and alcohol or water as a reducing agent to obtain the chiral secondary alcohol compound. According to the method disclosed by the invention, a combination of pinacol diborate and alcohol or water which are cheap, stable and easy to obtain is taken as a reducing agent, and a ketone compound is efficiently reduced to synthesize a corresponding chiral secondary alcohol compound in an aprotic organic solvent under the action of a chiral cobalt catalyst; in a chiral cobalt catalyst adopted by the method, when a chiral ligand is PAOR, an activating agent is NaBHEt3 or NaOtBu and an adopted raw material is aromatic ketone, the yield is 80% or above, and the optical purity is 90% or above; and when the adopted raw material is alkane ketone, the yield can reach 70% or above, and the optical purity can reach 80% or above.

Redox-driven deracemization of secondary alcohols by sequential ether/O2-mediated oxidation and Ru-catalyzed asymmetric reduction

The deracemization of benzylic alcohols has been achieved using a redox-driven one-pot two-step process. The racemic alcohols were oxidized by bis(methoxypropyl) ether and oxygen to give the ketone intermediates, followed by an asymmetric transfer hydrogenation with a chiral ruthenium catalyst. This compatible oxidation/reduction process gave the enantiomerically enriched alcohols with up to 95% ee values.