146328-18-9Relevant academic research and scientific papers
Indole derivatives as a new class of steroid 5α-reductase inhibitors
Takami, Hitoshi,Koshimura, Hirokazu,Kishibayashi, Nobuyuki,Ishii, Akio,Nonaka, Hiromi,Aoyama, Shiro,Kase, Hiroshi,Kumazawa, Toshiaki
, p. 5047 - 5052 (2007/10/03)
A series of indole derivatives with varied substituents on the α,β- unsaturated double bond were synthesized and evaluated for their ability to inhibit rat prostatic 5α-reductase. Compounds possessing an ethyl substituent at the β-position of the double b
(E)-4-amino>phenoxy>butyric Acid Derivatives: A New Class of Steroid 5α-Reductase Inhibitors in the Rat Prostate. 1
Kumazawa, Toshiaki,Takami, Hitoshi,Kishibayashi, Nobuyuki,Ishii, Akio,Nagahara, Yoshitomo,et al.
, p. 2887 - 2892 (2007/10/02)
A series of (E)-4-amino>phenoxy>butyric acid derivatives was prepared, and the derivatives were demonstrated to be potent inhibitors of steroid 5α-reductase in the rat prostate.The structure - activity relationships wer
INDOLE DERIVATIVES WHICH INHIBIT STEROID 5alpha REDUCTASE
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, (2008/06/13)
The present invention provides Indole derivatives represented by the formula (I) wherein R1, R2and R3 independently represent hydrogen or lower alkyl; R4 represents hydrogen, lower alkyl or cycloalkyl; R5 represents hydrogen, substituted or unsubstituted
