14633-65-9

Upstream product

• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 100-52-7 benzaldehyde 
• 160290-10-8 O-acetyl-3-phenyl-2-(trifluoromethyl)prop-1-en-3-ol 
• 109-72-8 n-butyllithium 
• 1187552-63-1 C₁₈H₁₉F₃OSi 

Downstream Products

• 1246788-84-0 [1-(prop-2-ynyloxy)-2-(trifluoromethyl)allyl]benzene 
• 160290-10-8 O-acetyl-3-phenyl-2-(trifluoromethyl)prop-1-en-3-ol 

Relevant academic research and scientific papers

A facile access for multisubstituted trifluoromethyl olefins by visible light catalysis

Induced by visible light, a green approach for the highly substituted trifluoromethyl olefins has been developed by using alkyl boronic acid as a carbon radical precursor and the Boc-modified trifluoromethylated Baylis-Hillman adduct (BMTBHA) as an accept

Method for Producing Fluorine-Containing Substituted Compound and Fluorine-Containing Substituted Compound

A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.

Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

α-(Trifluoromethyl)vinyllithium was generated and used for the reaction with electrophiles at -78 °C in a flow microreactor although the batch reaction should be carried out at ca. -100°C, and the method was applied to continuous flow three-component synt

Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization

This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom econom

Rapid and slow generation of 1-trifluoromethylvinyllithium: syntheses and applications of CF3-containing allylic alcohols, allylic amines, and vinyl ketones

1-(Trifluoromethyl)vinylation is accomplished in two protocols by the in situ generation of thermally unstable 3,3,3-trifluoroprop-1-en-2-yllithium (1):1) a rapid lithium-halogen-exchange reaction of 2-bromo-3,3,3-trifluoroprop- 1-ene (2) takes effect wit

Generation and reactions of trifluoromethylethenyl titanium(II) species

(Chemical Equation Presented) The reaction of (trifluoromethyl) dimethylphenylsilylacetylene and (η2-propene)Ti(O iPr)2 generated in situ smoothly proceeded giving the corresponding (η2-1-dimethylphenylsilyl-2-t

A facile synthesis of N-[2-(trifluoromethyl)allyl]amides and their transformation into angularly trifluoromethylated bicyclic cyclopentenones

On treatment with sec-BuLi at -105°C, 2-bromo-3,3,3-trifluoropropene undergoes rapid lithium-halogen exchange to generate thermally unstable 1-(trifluoromethyl)vinyllithium, which reacts with W-tosylimines to afford N-[2-(trifluoromethyl)allyl] amides in high yield. Propargylation of the amides, followed by the Pauson-Khand reaction, readily provides pyrrolidine ring-fused cyclopentenones with an angular trifluoromethyl group. Copyright

1-(Trifluoromethyl)vinylation via oxirane or oxetane ring-opening: A facile synthesis of 4- or 5-hydroxy-functionalized 2-trifluoromethyl-1-alkenes

Introduction of a 1-(trifluoromethyl)vinyl group has been accomplished by the reaction of thermally unstable 1-(trifluoromethyl)vinyllithium (1) with strained cyclic ethers. Treatment of 2-bromo-3,3,3-trifluoropropene with butyllithium generates 1, which in turn reacts with several oxiranes or an oxetane at -100 °C in the presence of BF3·OEt2 to afford the corresponding 2-trifluoromethyl-1-alkenes bearing a hydroxy group on the 4- or 5-position. An enantiopure oxirane undergoes ring-opening without racemization, providing an optically active homoallyllic alcohol with a 3-trifluoromethyl group. Georg Thieme Verlag Stuttgart.

Preparation of optically active 2-(trifluoromethyl)alkan-1-ols by catalytic asymmetric hydrogenation

The hydrogenation of (E)-2-(trifluoromethyl)alk-2-en-1-ols catalyzed by Ru-BINAP and Rh-BINAP has been carried out with good enantiomeric excess (71percent-83percent ee).Ru-BINAP-catalyzed hydrogenation converted 2-trifluoromethylacrylic acid to the corresponding saturated acid, the esterification and reduction of which gave optically active 2-(trifluoromethyl)propan-1-ol in 80percent ee.

Zinc-promoted Barbier-type Reaction of 2-Bromo-3,3,3-trifluoropropene with Aldehydes

A zinc-promoted Barbier-type reaction of 2-bromo-3,3,3-trifluoropropene with aldehydes to give CF3-substituted allylic alcohols in good yields is reported.