146333-24-6

Basic information

• Product Name: 3-O-benzyl diosgenin
• Synonyms: 3-O-benzyl diosgenin
• CAS NO: 146333-24-6
• Molecular Weight: 504.753
• Mol File: 146333-24-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-O-benzyl diosgenin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-benzyl diosgenin(146333-24-6)
• EPA Substance Registry System: 3-O-benzyl diosgenin(146333-24-6)

Safety Data

• Hazardous Substances Data: 146333-24-6(Hazardous Substances Data)

Upstream product

• 100-44-7 benzyl chloride 
• 512-04-9 diosgenin 
• 100-39-0 benzyl bromide 

Downstream Products

• 210687-05-1 3β-O-benzylchlorogenin 
• 210687-23-3 (3S,5S,6R,8R,9S,10R,13R,14S,15R,16R,17R)-3,6-Bis-benzyloxy-17-((1R,5R)-6-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthrene-15,16-diol 
• 210687-09-5 (25R)-3β-(benzyloxy)-5α-spirostan-6β-ol 
• 210687-15-3 (3S,5S,6R,8R,9S,10R,13S,14S,17R)-3,6-Bis-benzyloxy-17-[(1R,5R)-6-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-16-one 
• 210687-13-1 (3S,5S,6R,8R,9S,10R,13S,14S,16S,17R)-3,6-Bis-benzyloxy-17-[(1R,5R)-6-(tert-butyl-dimethyl-silanyloxy)-1,5-dimethyl-hexyl]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-16-ol 
• 210687-17-5 [(2R,6R)-6-((3S,5S,6R,8R,9S,10R,13R,14S,17S)-3,6-Bis-benzyloxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-heptyloxy]-tert-butyl-dimethyl-silane 
• 210687-21-1 (3S,5S,6R,8R,9S,10R,13S,14S,15R,17R)-3,6-Bis-benzyloxy-15-hydroxy-17-((1R,5R)-6-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-16-one 
• 210687-10-8 (25R)-3β,6β-bis(benzyloxy)-5α-spirostane 
• 210687-18-6 (2R,6R)-6-((3S,5S,6R,8R,9S,10R,13R,14S,17S)-3,6-Bis-benzyloxy-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-heptan-1-ol 
• 210687-12-0 (3S,5S,6R,8R,9S,10R,13S,14S,16S,17R)-3,6-Bis-benzyloxy-17-((1R,5R)-6-hydroxy-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-16-ol 
• 484002-10-0 laxogenin-3-yl 2,3-di-O-benzoyl-6-O-(2,3,4-tri-O-benzoyl-L-arabinopyranosyl)-D-glucopyranoside 
• 484002-08-6 laxogenin-3-yl 2,3,4,6-tetra-O-benzoyl-D-glucopyranoside 
• 484002-14-4 laxogenin-3-yl 2,3-O-di-benzoyl-4,6-O-benzylidene-D-glucopyranoside 

Relevant articles and documents

Unexpected fragmentation of 16β-acetoxy-22-oxocholestanes on the action of methylenetriphenylphosphorane

Treatment of 16β-acetoxy-22-oxocholestanes with methylenetriphenylphosphorane results in the cleavage of C22-C23 bond and formation of bisnorcholanic (22→16)-lactones. The analogous fragmentation also partially proceeds on ButOK action.

Diosgenin derivative as well as preparation method and application thereof (by machine translation)

The invention provides a diosgenin derivative and a preparation method thereof as well as a preparation, method and application of the diosgenin derivative, and the diosgenin derivative has the: structure shown in a formula (I) shown in the specification. The compound of, R the present invention has good inhibitory, activity against bile duct cancer, cells and human; and, pancreatic cancer cell proliferation, (I) and the compound of the present invention has. good inhibition activity for bile duct cancer cells and human pancreatic cancer cells, and is remarkably, superior to that of the clinical application, 5 . (by machine translation)

Synthesis of a chlorogenin glycoside library using an orthogonal protecting group strategy

Naturally occurring spirostanol saponins bear a chacotriose, α-l-rhamnopyranosyl-(1→2)-[α-l-rhamnopyranosyl-(1→4)] -β-d-glucopyranose residue as the oligosaccharide moiety which is believed to be important for biological activity. Herein the development of a concise, combinatorial method for the synthesis of two series of glycan variants at the 2′ and/or 4′ positions of chacotriose is described and the structure-activity relationships of the glycone part at 3-OH of chlorogenin investigated. These compounds were found to be weakly-cytotoxic toward leukemia cell lines CCRF and HL-20, indicating that the chacotriose moiety is important for anticancer activity.