146351-93-1

Basic information

• Product Name: 2-AMINO-3,5-DIMETHYL-BENZONITRILE
• Synonyms: 2-AMINO-3,5-DIMETHYL-BENZONITRILE;Benzonitrile, 2-amino-3,5-dimethyl- (9CI)
• CAS NO: 146351-93-1
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.19
• Product Categories: AMINEPRIMARY
• Mol File: 146351-93-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-3,5-DIMETHYL-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3,5-DIMETHYL-BENZONITRILE(146351-93-1)
• EPA Substance Registry System: 2-AMINO-3,5-DIMETHYL-BENZONITRILE(146351-93-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3439
• Hazardous Substances Data: 146351-93-1(Hazardous Substances Data)

Usage

General Description

2-AMINO-3,5-DIMETHYL-BENZONITRILE, also known as 3,5-dimethyl-2-aminobenzonitrile, is a chemical compound with the molecular formula C9H10N2. It is a benzene derivative with a nitrile group and amino group attached to the aromatic ring. 2-AMINO-3,5-DIMETHYL-BENZONITRILE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a chemical building block in the production of dyes, pigments, and other organic compounds. 2-AMINO-3,5-DIMETHYL-BENZONITRILE is a colorless to pale yellow solid that is soluble in organic solvents and has a characteristic odor. It is important to handle and use this compound with caution, as it may be harmful if inhaled, ingested, or comes into contact with the skin.

Upstream product

• 95-68-1 2,4-Xylidine 
• 1262111-12-5 2-azido-3,5-dimethylbenzonitrile 
• 75-16-1 methylmagnesium bromide 
• 41825-73-4 2-bromo-4,6-dimethylaniline 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 1262111-12-5 2-azido-3,5-dimethylbenzonitrile 

Relevant articles and documents

Synthesis of benzotriazine and aryltriazene derivatives starting from 2-azidobenzonitrile derivatives

3-Substituted 3,4-dihydro-4-imino-1,2,3-benzotriazine derivatives 7 were formed from 2-azidobenzonitriles 4 as starting materials on treatment with Grignard or lithium organic reagents. In some cases these procedures gave aryltriazenes 10 and 11 as products. All compounds were identified by NMR spectroscopy and the structures of three products, namely 7a, 10a and 11i, were corroborated by X-ray crystallography. The reactions of 2-azidobenzonitrile derivatives with Grignard reagents have been investigated. These reactions, depending on the type of Grignard reagent and the substituents on the 2-azidobenzonitrile derivatives, resulted in benzotriazines and triazenes. Copyright

N-heteroaryl aryl-substituted thienyl-furyl-and pyrrolyl-sulfonamides and derviatives thereof that modulate the activity of endothelin

Thienyl-, furyl- and pyrrolyl-sulfonamides, formulations of pharmaceutically-acceptable salts thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thienylsulfonamides, N-(isoxazolyl)furylsulfonamides and N-(isoxazolyl)pyrrolylsulfonamides, formulations thereof and methods using these sulfonamides for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit the activity of endothelin are also provided.