146366-92-9

Upstream product

• 157493-96-4 2-(2-(3-phenylpropionyl)-phenoxy)-essigsaeureethylester 
• 91401-72-8 2-(ω-phenyl-propionyl)-phenoxy-acetic acid 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 68-12-2 N,N-dimethyl-formamide 
• 85148-33-0 3-(2-phenylethyl)benzofuran 

Downstream Products

• 157493-97-5 α-hydroxy-3-(2-phenylethyl)-2-benzofuranacetonitrile 
• 146366-94-1 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine 
• 146366-93-0 3-(2-phenylethyl)-α-(2-tetrahydropyranyloxy)-2-benzofuranacetonitrile 
• 146396-22-7 3-(2-phenylethyl)-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine 

Relevant academic research and scientific papers

Efficient synthesis of chiral benzofuryl β-amino alcohols via a catalytic asymmetric Henry reaction

Chiral β-amino alcohol ligands were found effective for the copper(ii)-catalyzed asymmetric Henry reaction of benzofuran-2-carbaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcohols with satisfactory enantioselectivities (up to 98% ee). Using this catalytic protocol, bioactive (S)-benzofuryl β-amino alcohols could be conveniently prepared in short steps.

New Benzofuran-Type Antiarrhythmic Compounds Related to Propafenone

Synthesis of two benzofuran compounds (2a and 2b), which are structurally and - by their action as sodium channel blockers - also pharmacologically related to propafenone is described.