3-(2-phenylethyl)-2-benzofurancarbaldehyde

Base Information

• Chemical Name: 3-(2-phenylethyl)-2-benzofurancarbaldehyde
• CAS No.: 146366-92-9
• Molecular Formula: C₁₇H₁₄O₂
• Molecular Weight: 250.297
• Mol file: 146366-92-9.mol

Synonyms:3-(2-phenylethyl)-2-benzofurancarbaldehyde

Chemical Property of 3-(2-phenylethyl)-2-benzofurancarbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(2-phenylethyl)-2-benzofurancarbaldehyde

There total 5 articles about 3-(2-phenylethyl)-2-benzofurancarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 3-(2-phenylethyl)benzofuran (85148-33-0) → 3-(2-phenylethyl)-2-benzofurancarbaldehyde (146366-92-9)

Guidance literature:

With trichlorophosphate; at 100 ℃;

Reference yield: 62.0%

ethyl 3-phenethylbenzofuran-2-carboxylate → 3-(2-phenylethyl)-2-benzofurancarbaldehyde (146366-92-9)

Guidance literature:

ethyl 3-phenethylbenzofuran-2-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

With Dess-Martin periodane; In dichloromethane;

DOI:10.1039/c6ob02569b

Reference yield:

2'-hydroxy-3-phenylpropiophenone (3516-95-8) → 3-(2-phenylethyl)-2-benzofurancarbaldehyde (146366-92-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / K₂CO₃ / acetone / 24 h / Heating

2: 84 percent / Na₂CO₃ / H₂O / 3 h / Heating

3: 88 percent / NaOAc, Ac₂O / 2 h / Heating

4: 95.6 percent / POCl₃ / 100 °C

With sodium acetate; acetic anhydride; sodium carbonate; potassium carbonate; trichlorophosphate; In water; acetone;

upstream raw materials:

N,N-dimethyl-formamide

3-(2-phenylethyl)benzofuran

2'-hydroxy-3-phenylpropiophenone

2-(ω-phenyl-propionyl)-phenoxy-acetic acid

Downstream raw materials:

α-hydroxy-3-(2-phenylethyl)-2-benzofuranacetonitrile

3-(2-phenylethyl)-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine

3-(2-phenylethyl)-α-(2-tetrahydropyranyloxy)-2-benzofuranacetonitrile

3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine