146384-56-7

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 1147830-51-0 N-(4-chlorophenyl)sulfonyl-2-ethynylaniline 
• 123-72-8 butyraldehyde 
• 120-72-9 indole 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 25688-25-9 1-(2-nitrophenyl)-1H-indole 
• 1189132-38-4 1-(4-chlorophenylsulfonyl)-1H-indole-3-sulfonyl chloride 
• 104142-23-6 1-(1-((4-chlorophenyl)sulfonyl)-1H-indol-3-yl)ethan-1-one 
• 120-72-9 indole 

Relevant academic research and scientific papers

Electron Transfer Photoredox Catalysis: Development of a Photoactivated Reductive Desulfonylation of an Aza-Heteroaromatic Ring

Herein, we report a protocol for desulfonylation of aza-heteroaromatic rings via photoinduced electron transfer and hydrogen atom transfer. This general protocol has a wide substrate range and moderate to good yields. The utility of the method was demonstrated by the chemoselective desulfonylation of a molecule containing both an aliphatic and an aromatic sulfonamide. (Figure presented.).

N - substituted benzene sulfonyl -3 - propionyl indole derivatives, preparation method and application

The invention discloses an N-substituted benzenesulfonyl-3-propionyl indole derivative, a preparation method and application and belongs to the technical field of organic synthesis. The structural formula of the N-substituted benzenesulfonyl-3-propionyl i

Access to biaryl sulfonamides by palladium-catalyzed intramolecular oxidative coupling and subsequent nucleophilic ring opening of heterobiaryl sultams with amines

The installation of sulfonamide pharmacophores on heterobiaryls has successfully been executed by a previously unknown palladium-catalyzed intramolecular oxidative coupling in N-arylsulfonyl heterocycles followed by novel ring opening of heterobiaryl sultams with amine nucleophiles. The protocol has a wide scope of substrates warranting broad applications in the synthesis of heterobiaryls containing an o-sulfonyl or carboxyl functional group.

Synthesis and quantitative structure-activity relationship (QSAR) study of novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives as nematicidal agents

In continuation of our program aimed at the discovery and development of natural-product-based pesticidal agents, 54 novel N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives were prepared, and their structures were well characterized by 1

An efficient synthesis of N-arylsulfonylindoles from indoles and arylsulfonyl chlorides in the presence of triethylbenzylammonium chloride (TEBA) and NaOH

An efficient synthesis of N-arylsulfonylindoles from indoles and arylsulfonyl chlorides in the presence of triethylbenzylammonium chloride (TEBA) and NaOH at room temperature is described.

Anti HIV-1 agents 5: Synthesis and anti-HIV-1 activity of some N-arylsulfonyl-3-acetylindoles in vitro

In continuation of our program aimed at the discovery and development of compounds with superior anti-human immunodeficiency virus type 1 (HIV-1) activity, 21N-arylsulfonyl-3-acetylindole analogs (2a-u) were synthesized and preliminarily evaluated as HIV-

Facile synthesis of 1,2,3,4-tetrahydro-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization

Two direct synthetic methods of 1,2,3,4-tetrahydro-/?-carboline derivatives have been developed. After initial indole formation by copper- catalyzed domino three-component coupling-cyclization using an appropriate ethynylaniline, aldehyde, and a secondary

Anti human immunodeficiency virus-1 (HIV-1) agents 3. Synthesis and in vitro anti-HIV-1 activity of some N-arylsulfonylindoles

In order to find compounds with superior anti human immunodeficiency virus type 1 (HIV-1) activity, twelve simple N-arylsulfonylindoles (3a-l) were synthesized and preliminarily evaluated as HIV-1 inhibitors in vitro for the first time. Several compounds demonstrated significant anti-HIV-1 activity, especially N-(3-nitrobenzene) sulfonyl-6-methylindole (3h) and N-(3-nitrobenzene)sulfonylindole (3i) showed the highest anti-HIV-1 activity with EC50 values of 0.26 and 0.74 μg/ml, and TI values of 543.78 and >270.27, respectively.

Novel furanylarylene arylsulfonylindolesulfonamides: Synthesis and their antibacterial evaluation

An array of furanylarylene arylsulfonylindolesulfonamides was synthesized through multi-step synthetic protocols involving bromination, stannylation, Stille cross coupling, reduction, arylsulfonylation, chlorosulfonylation, and condensation reactions. As

Triflic acid controlled successive annelation of aromatic sulfonamides: an efficient one-pot synthesis of N-sulfonyl pyrroles, indoles and carbazoles

A novel one-pot synthesis of N-substituted heterocycles via successive cyclization/annelation starting from primary sulfonamides is described. This process directly leads to N-sulfonyl pyrroles, indoles and carbazoles. The selection of an appropriate reac