146459-54-3

Upstream product

• 33644-25-6 (2S)-3-fluoropropane-1,2-diol 
• 98-59-9 p-toluenesulfonyl chloride 
• 445030-22-8 (S)-4-tosyloxymethyl-1,3,2-dioxathiolane-2,2-dioxide 
• 41274-09-3 (R)-3-tosyloxy-1,2-propanediol 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 
• 113826-06-5 (R)-glycidyl tosylate 

Downstream Products

• 146459-55-4 (S)-1-fluoro-2-methoxymethoxypropyl p-toluenesulfonate 
• 146459-58-7 (S)-2-[(diisopropoxyphosphoryl)methoxy]-3-fluoropropyl 4-methylbenzenesulphonate 
• 146459-56-5 (S)-2-acetoxymethoxy-3-fluoropropyl p-toluenesulfonate 

Relevant academic research and scientific papers

Tetrahydroimidazo[1,5-d][1,4]oxazepine compound

A compound represented by formula (I): wherein R is a methyl group or the like, R1 is a fluorine atom or the like, R2 is a hydrogen atom or a fluorine atom, R3 is a hydrogen atom, R4 is an ethyl group or the lik

Tetrahydroimidazo(1,5-D)[1,4]Oxazepine Derivative

A compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof works as an mGluR2 antagonist, and is applicable as a therapeutic agent for neurological disorders related to glutamate dysfunction and diseases involving th

Nucleophilic reaction of glycidol tosylate and the corresponding cyclic sulfate with various nucleophiles: A comparative study

The nucleophilic reaction of glycidol tosylate and the corresponding cyclic sulfate tosylate have been carried out with a number of nucleophiles to study the possible attack of nucleophiles at C1, C2 or C3 positions. The regioselectivity and reactivity of both the substrates i.e. epoxide tosylate 1 and the corresponding cyclic sulfate 2 have been compared and established that under similar conditions cyclic sulfate counterpart shows better regioselectivity and better reactivity than the corresponding epoxide.

Di(2-propyl)esters of 1-fluoro-2-phosphonomethoxy-3-P-to-luenesulfonyloxypropanes, their producing and utilization

The invention relates to new compounds, di(2-propyl) esters of (R)-, (S)- and (RS)-1-fluoro-2-phosphonomethoxy-3-p-toluenesulfonyloxypropane and the method of producing them. The compounds can be used with advantage in the preparation of N-(3-fluoro-2-pho

SYNTHESIS OF N-(3-FLUORO-2-PHOSPHONOMETHOXYPROPYL) (FPMP) DERIVATIVES OF HETEROCYCLIC BASES

A new groupnof compounds has been prepared: N-(3-fluoro-2-phosphonomethoxypropyl) (FPMP) derivatives of purine and pyrimidine bases which exhibit a significant selective activity against a broad spectrum of retroviruses.Racemic N-(3-fluoro-2-phosphonomethoxypropyl) derivatives of adenine (V), guanine (IX), cytosine (XIII), 2,6-diaminopurine (XXI), 3-deazaadenine (XVII), xanthine (X) and hypoxanthine (VI) were prepared from the corresponding n-(3-fluoro-2-hydroxypropyl) derivatives after protection of amino group at the heterocyclic ring by selective benzoylation, reaction with diisopropyl p-toluenesulfonyloxymethylphosphonate (II), and subsequent removal of the protecting groups.Chiral FPMP derivatives were prepared by reaction of heterocyclic base with corresponding chiral synthon (XXX; XXXVII) followed by deprotection.The required chiral synthons were obtained from enantiomeric 3-fluoro-1,2-propanediols by two methods.In the first, the primary hydroxyl group was tritylated, the obtained derivative was reacted with compound II, the trityl group was removed and the product was mesylated to give synthon XXXVII.The second pathway considered tosylation of the primary hydroxyl group and conversion of the secondary hydroxyl into the acetoxymethyl ether via the methoxymethyl ether; treatment of the acetoxy compound with bromotrimethylsilane and triisopropyl phosphite afforded the desired synthon XXX.