146462-19-3Relevant academic research and scientific papers
Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5
Dan, Akihito,Shiyama, Takaaki,Yamazaki, Kazuto,Kusunose, Naoto,Fujita, Katsuya,Sato, Hideshi,Matsui, Kazutaka,Kitano, Masafumi
, p. 4085 - 4090 (2007/10/03)
HTS and the following synthesis of a series of the compounds led us to the discovery of hydroxamic acid analogs as potent dual inhibitors of phosphodiesterase (PDE)-1 and 5. These compounds have highly related structure and deviation of the structure usua
Pyridine compounds which are useful as leukotriene B4 antagonist
-
, (2008/06/13)
Leukotriene B4 antagonists of the formula: STR1 wherein each symbol is as defined in the specification, processes for producing them, and pharmaceutical compositions containing them. The compounds of the present invention are very useful as the drugs for the treatment of allergic and inflammatory diseases.
