4460-42-8

Basic information

• Product Name: 1-(5-ethyl-2,4-dihydroxy-phenyl)ethanone
• CAS NO: 4460-42-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2005
• Mol File: 4460-42-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 348.301°C at 760 mmHg
• Flash Point: 178.643°C
• Density: 1.196g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 1-(5-ethyl-2,4-dihydroxy-phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-ethyl-2,4-dihydroxy-phenyl)ethanone(4460-42-8)
• EPA Substance Registry System: 1-(5-ethyl-2,4-dihydroxy-phenyl)ethanone(4460-42-8)

Safety Data

• Hazardous Substances Data: 4460-42-8(Hazardous Substances Data)

Usage

General Description

1-(5-ethyl-2,4-dihydroxy-phenyl)ethanone is a chemical compound with the molecular formula C10H12O3. It is also known as ethyl-2,4-dihydroxyacetophenone and is a derivative of acetophenone. 1-(5-ethyl-2,4-dihydroxy-phenyl)ethanone is a white crystalline solid with a sweet, floral odor. It is used in the production of flavors and fragrances, as well as in the synthesis of pharmaceutical compounds. Its aromatic and hydroxyl groups make it useful in various chemical reactions, and it is also used as a reagent in organic synthesis. Additionally, it exhibits antioxidant and antifungal properties, making it potentially useful in the development of pharmaceutical and cosmetic products.

Upstream product

• 2896-60-8 4-ethyl-1,3-benzenediol 
• 75-36-5 acetyl chloride 
• 75-05-8 acetonitrile 
• 64-19-7 acetic acid 
• 4223-83-0 5-ethyl-6-methoxy-2,3-dimethyl-benzofuran 
• 625-60-5 ethyl thioacetate 
• 373-61-5 boron trifluoride diacetate 
• 108-46-3 recorcinol 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 127265-10-5 4-ethylresorcinol acetate 
• 2161-86-6 2,4-diacetylphloroglucinol 
• 108-22-5 Isopropenyl acetate 

Downstream Products

• 101594-92-7 1-(4-(benzyloxy)-5-ethyl-2-hydroxyphenyl)ethan-1-one 
• 117690-97-8 5-(4-Acetyl-2-ethyl-5-hydroxyphenoxy)-pentanenitrile 
• 117690-59-2 7-(4-acetyl-2-ethyl-5-hydroxyphenoxy)heptanenitrile 
• 117690-81-0 7-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-dimethylheptanenitrile 
• 4223-85-2 4-methoxy-2-hydroxy-5-ethylacetophenone 
• 52959-32-7 4,6-diethylresorcinol 
• 146462-19-3 6-[(4-acetyl-2-ethyl-5-hydroxyphenoxy)methyl]pyridine-2-carboxylic acid 
• 81468-74-8 2-ethoxy-4-methoxy-5-ethylacetophenone 
• 81468-77-1 2-ethoxy-4-methoxy-5-ethylacetophenone oxime 
• 6345-77-3 6-ethyl-7-benzyloxy-4-oxo-4H-chromene-2-carboxylic acid ethyl ester 
• 860189-40-8 4-(5-ethyl-4-benzyloxy-2-hydroxy-phenyl)-2,4-dioxo-butyric acid ethyl ester 
• 140660-12-4 6-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-dimethylhexanenitrile 
• 1001385-69-8 1-(2,4-bis(benzyloxy)-5-ethylphenyl)ethanone 

Relevant articles and documents

Thioesters as Acyl Donors in Biocatalytic Friedel-Crafts-type Acylation Catalyzed by Acyltransferase from Pseudomonas Protegens

Functionalization of aromatic compounds by acylation has considerable significance in synthetic organic chemistry. As an alternative to chemical Friedel-Crafts acylation, the C-acyltransferase from Pseudomonas protegens has been found to catalyze C?C bond formation with non-natural resorcinol substrates. Extending the scope of acyl donors, it is now shown that the enzyme is also able to catalyze C?S bond cleavage prior to C?C bond formation, thus aliphatic and aromatic thioesters can be used as acyl donors. It is worth to mention that this reaction can be performed in aqueous buffer. Identifying ethyl thioacetate as the most suitable acetyl donor, the products were obtained with up to >99 % conversion and up to 88 % isolated yield without using additional base additives; this represents a significant advancement to prior protocols.

Phenyl 1, 2 - isoxazole or phenyl 1, 2 - pyrazole compound and use thereof (by machine translation)

The invention discloses the following formula of phenyl 1, 2 - different oxazole or 1, 2 - pyrazole compounds with use. Through the biological activity tests show that, the compound inhibiting heat shock protein 90 activity. Therefore, the invention phenyl 1, 2 - different oxazole or 1, 2 - pyrazole compounds can be used as a heat shock protein 90 inhibitor for the treatment of cancer. (by machine translation)

4,5-Diarylisoxazole Hsp90 chaperone inhibitors: Potential therapeutic agents for the treatment of cancer

Inhibitors of the Hsp90 molecular chaperone are showing considerable promise as potential chemotherapeutic agents for cancer. Here, we describe the structure-based design, synthesis, structure - activity relationships and pharmacokinetics of potent small-molecule inhibitors of Hsp90 based on the 4,5-diarylisoxazole scaffold. Analogues from this series have high affinity for Hsp90, as measured in a fluorescence polarization (FP) competitive binding assay, and are active in cancer cell lines where they inhibit proliferation and exhibit a characteristic profile of depletion of oncogenic proteins and concomitant elevation of Hsp72. Compound 40f (VER-52296/NVP-AUY922) is potent in the Hsp90 FP binding assay (IC50 = 21 nM) and inhibits proliferation of various human cancer cell lines in vitro, with GI50 averaging 9 nM. Compound 40f is retained in tumors in vivo when administered i.p., as evaluated by cassette dosing in tumor-bearing mice. In a human colon cancer xenograft model, 40f inhibits tumor growth by ～50%.