213765-35-6

Upstream product

• 80994-44-1 {[(tert-butoxycarbonyl)oxy]amino}(phenyl)acetonitrile 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 99-63-8 benzene-1,3-dicarbonyl dichloride 
• 146504-07-6 tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate 

Downstream Products

• 226383-89-7 N,N'-bis<2'-amino-(1'R,2'R)-cyclohexyl>isophthalamide 

Relevant academic research and scientific papers

Stereoselective recognition of tripeptides guided by encoded library screening: Construction of chiral macrocyclic tetraamide ruthenium receptor for peptide sensing

(Chemical Equation Presented) Molecule sensor 1 is devised by incorporating the reporting unit of ruthenium(II) complex and two recognition motifs of chiral cyclotetraamides on the sidearms. The target binding tripeptides for sensor 1 were readily identified by using an encoded library screening method. This solid-phase screening indicated a preferable binding of molecule 1 with D-alanine over the L-isomer. The optical and NMR studies for the binding events of 1 with tripeptides Ac-Ala-Gly-Ala-NHC12H25 in the solution phase showed a consistent trend for the stereoselective recognition of the DD-isomer over the LD-, DL-, and LL-isomers.

Synthesis of a Chiral Macrocyclic Dibenzodicyclohexanotetraamide-Containing Stationary Phase for Liquid Chromatography

Allyloxy-substituted macrocyclic dibenzodicyclohexanotetraamide 2 was prepared by the following sequence. Mono-Boc-protected chiral 1,2-cyclohexanediamine (3) was treated with isophthaloyl chloride followed by removal of the Boc group to form bisisophthal