1465764-07-1Relevant academic research and scientific papers
1,4-addition reaction of 5H-oxazol-4-ones to allenic esters and ketones catalyzed by chiral guanidines
Jin, Nari,Misaki, Tomonori,Sugimura, Takashi
, p. 894 - 896 (2013/09/02)
In this paper, a chiral guanidine-catalyzed 1,4-addition reaction of 5H-oxazol-4-ones to allenic esters and ketones is described. 5H-Oxazol-4-ones substituted with a 2-chlorophenyl group were suitable pronucleophiles that gave high enantioselectivities. Subsequent hydrolysis of the obtained adduct gave the corresponding γ-butenolide ester without loss of enantiopurity and was transformed into (+)-crobarbatic acid in a few steps.
