Tetrahedron Letters p. 7609 - 7612 (1992)
Update date:2022-08-04
Topics:
Pannecouque
Wigerinck
Van Aerschot
Herdewijn
Synthesis of dimeric nucleoside building blocks with a N-cyanoguanidine linkage was performed by reaction of 3'-amino-3'-deoxythymidine with S,S-dimethyl-N-cyanodithioimidocarbonate followed by reaction of the obtained isothiourea with 5'-amino-2',5'-dideoxynucleosides. These dimers were protected in the 5'-position and converted into their phosphoramidites. Oligonucleotides were synthesized using these building blocks.
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