1467-86-3Relevant articles and documents
Process for the preparation of ibodutant (MEN15596) and related intermediates
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Page/Page column 18, (2013/05/09)
This invention relates to a novel process for synthesizing the product ibodutant shown in the figure below, consisting of a small number of high-yield steps involving reagents and solvents with low environmental impact, characterized by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesized by coupling of 6-methyl-2-benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalizations of 4-aminomethylpiperidine (2).
PROCESS FOR THE PREPARATION OF IBODUTANT (MEN15596) AND RELATED INTERMEDIATES
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, (2012/03/27)
This invention relates to a novel process for synthesising the product ibodutant shown in the figure below, consisting of a small number of high-yield steps involving reagents and solvents with low environmental impact, characterised by the coupling of tw
PROCESS FOR THE PREPARATION OF IBODUTANT (MEN15596) AND RELATED INTERMEDIATES
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Page/Page column 9; 24; 25, (2010/12/18)
This invention relates to a novel process for synthesising the product ibodutant shown in the figure below, consisting of a small number of high- yield steps involving reagents and solvents with low environmental impact, characterised by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesised by coupling of 6-methyl-2- benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalisations of 4-aminomethylpiperidine (2).
An improved synthesis of substituted benzo[b]thiophenes using microwave irradiation
Allen, Daniel,Callaghan, Owen,Cordier, Frederic L.,Dobson, David R.,Harris, John R.,Hotten, Terry M.,Owton, W. Martin,Rathmell, Richard E.,Wood, Virginia A.
, p. 9645 - 9647 (2007/10/03)
An easy and high-yielding method for the synthesis of substituted benzo[b]thiophenes using microwave irradiation is described.