146715-07-3

Basic information

• Product Name: Cyclohexanecarboxamide, N-[2-[4-(2-hydroxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-
• CAS NO: 146715-07-3
• Molecular Formula: C24H32N4O2
• Molecular Weight: 408.544
• Mol File: 146715-07-3.mol

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxamide, N-[2-[4-(2-hydroxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxamide, N-[2-[4-(2-hydroxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-(146715-07-3)
• EPA Substance Registry System: Cyclohexanecarboxamide, N-[2-[4-(2-hydroxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-(146715-07-3)

Safety Data

• Hazardous Substances Data: 146715-07-3(Hazardous Substances Data)

Upstream product

• 162760-96-5 WAY-100635 
• 2719-27-9 cyclohexanylcarbonyl chloride 
• 146714-76-3 N-(2-(4-(2-hydroxyphenyl)piperazin-1-yl)ethyl)-N-(2-pyridinyl)amine 
• 146714-63-8 4-(2-methoxyphenyl)-1-(2-pyridinylaminocarbonyl)methylpiperazine 
• 155204-28-7 1-(2-methoxyphenyl)-4-(2-(2-pyridylamino)ethyl)piperazine 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 
• 5221-37-4 2-chloro-N-pyridin-2-ylacetamide 

Relevant articles and documents

Solid-phase radiosynthesis of [11C]WAY 100635

An efficient, fast and simple method is described for the radiosynthesis of the potent and selective 5-HT1A antagonist [O-methyl- 11C]-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide ([11C]WAY 100635). [11C]Iodomethane was effectively trapped on a C18 reverse-phase cartridge at ambient temperature where it reacted rapidly with the normethyl precursor, N-[2-[4-(2-hydroxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexane carboxamide. Following high performance liquid chromatography purification and formulation, [11C]WAY 100635 was obtained in high radiochemical yields (40%, uncorrected from [11C]Iiodomethane) in a synthesis time of 25 min with an average specific actvity of (at end-of-synthesis) 33 GBq/μmole (900 mCi/μmole).

Synthesis and in vitro and in vivo functional studies of Ortho- substituted phenylpiperazine and N-substituted 4-N-(o- methoxyphenyl)aminopiperidine analogues of WAY100635

WAY100635 (2), N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- pyridinyl)cyclohexane-carboxamide, is a silent serotonin 5-HT(1A) antagonist, which is now widely used to study the 5-HT(1A) receptor both in vivo and in vitro. In this paper, we describe

N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides

Piperazine derivatives of formula I and their pharmaceutically acceptable acid addition salts are 5-HT1A binding agents, particularly 5-HT1A antagonists and may be used, for example, as anxiolytics. In the formula A is C2-4 alkylene chain optionally substituted by lower alkyl, Z is oxygen or sulphur, R is hydrogen or lower alkyl, R1 is a mono or bicyclic aryl or heteroaryl radical, R2 is a mono or bicyclic heteroaryl radical and R3 is hydrogen or a specified radical such as lower alkyl, cycloalkyl, aryl, heteroaryl or optionally substituted amino.

Pre-clinical Development of a Radioligand for Studies of Central 5-HT1A Receptors in Vivo - [11C]WAY-100635

Syntheses of N-(2-(1-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl))-N-(2-pyridyl)-cyclohexanecarboxamide (WAY-100635) and its desmethyl and descyclohexylcarbonyl analogues are described. WAY-100635 has properties that favour its development as a radioligand f