1467592-46-6

Basic information

• Product Name: 4-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenyl-1H-benzimidazole
• Synonyms: 4-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenyl-1H-benzimidazole
• CAS NO: 1467592-46-6
• Molecular Weight: 276.297
• Mol File: 1467592-46-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenyl-1H-benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenyl-1H-benzimidazole(1467592-46-6)
• EPA Substance Registry System: 4-(3-methyl-1,2,4-oxadiazol-5-yl)-2-phenyl-1H-benzimidazole(1467592-46-6)

Safety Data

• Hazardous Substances Data: 1467592-46-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 603-81-6 2,3-diaminobenzoic acid 
• 22059-22-9 N-hydroxyacetamidine 
• 66630-72-6 2-Phenyl-4-benzimidazolylcarboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of novel benzimidazole derivatives bearing a heterocyclic ring at 4/5 position

A series of novel benzimidazole derivatives bearing a heterocyclic ring as oxadiazole (21-32), thiadiazole (33-34), triazole (35-36) were synthesized and evaluated for their activities against Coxsackie virus B3 and B6 in Vero cells. Compounds 21-26, 31-36 with moieties of 2'-pyridyl, 3'-pyridyl and 4'-pyridyl at the 2-position and oxadiazoles, thiadiazole, or triazole substituent at the 4- or 5-position generally displayed activities against CVB3 and CVB6. Especially compound 24 (IC50 = 1.08 μg/mL, SI = 61.7 against CVB3) was the promising candidate as lead compound for anti-enteroviral drug. It was observed in the incorporation of heterocyclic rings in benzimidazole at the 5-position could enhance their biological activities.