146762-13-2

Upstream product

• 141692-31-1 5-(4-benzylpiperazinyl)uracil 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 141692-44-6 Acetic acid (2R,3S,6S)-2-acetoxymethyl-6-[5-(4-benzyl-piperazin-1-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,6-dihydro-2H-pyran-3-yl ester 
• 141692-37-7 Acetic acid (2R,3S,6R)-2-acetoxymethyl-6-[5-(4-benzyl-piperazin-1-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-3,6-dihydro-2H-pyran-3-yl ester 
• 141692-51-5 5-(4-Benzyl-piperazin-1-yl)-1-((2R,5S,6R)-5-hydroxy-6-hydroxymethyl-5,6-dihydro-2H-pyran-2-yl)-1H-pyrimidine-2,4-dione 
• 141692-58-2 5-(4-Benzyl-piperazin-1-yl)-1-((2S,5S,6R)-5-hydroxy-6-hydroxymethyl-5,6-dihydro-2H-pyran-2-yl)-1H-pyrimidine-2,4-dione 
• 146762-38-1 1-(2,3,5-Tri-O-benzoyl-α-D-arabinofuranosyl)-5-(4-benzylpiperazino)-4-thiouracil 
• 146762-19-8 1-(2,3,5-Tri-O-benzoyl-α-D-arabinofuranosyl)-5-(4-benzylpiperazino)uracil 

Relevant academic research and scientific papers

Efficient synthesis of 2′-O-alkyl ribonucleosides using trichloroacetimidateDribofuranosides as ribosyl donors

Trichloroacetimidate-2-O-alkyl-3,5-O-TIPS-β- D-ribofuranoside glycosylates silylated nucleobases in a fast high-yielding and stereo selective reaction promoted by trimethylsilyl trifluoromethanesulfonate. This method has been applied to the syn

Asymmetric Synthesis and Biological Evaluation of β-L-(2R,5S)- and α-L-(2R,5R)-1,3-Oxathiolane-Pyrimidine and -Purine Nucleosides as Potential Anti-HIV Agents

In order to study the structure-acivity relationships of L-oxathiolanyl nucleosides as potential anti-HIV agents, a series of enantiomerically pure L-oxathiolanyl pyrimidine and purine nucleosides were synthesized and evaluated for anti-HIV-1 activity in human peripheral blood mononuclear (PBM) cells.The key intermediate 8 was synthesized starting from L-gulose via 1,6-thiaanhydro-L-gulopyranose.The acetate 8 was condensed with thymine, 5-substituted uracils and cytosines, 6-chloropurine, and 6-chloro-2-fluoropurine to give pyrimidine and purine nucleosides.Upon evaluation of these final nucleosides, the 5-fluorocytosine derivative 51 was found to be the most potent compound among those tested.In the case of 5-substituted cytosine analogues, the antiviral potency was found to be in the following decreasing order: cytosine (β-isomer) > 5-iodocytosine (β-isomer) > 5-fluorocytosine (α-isomer) > 5-methylcytosine (α-isomer) > 5-methylcytosine (β-isomer) > 5-bromocytosine (β-isomer) > 5-chlorocytosine (β-isomer).Among the thymine, uracil, and 5-substituted uracil derivatives, thymine (α-isomer) and uracil (β-isomer) derivatives exhibited moderate anti-HIV activity.In the purine series, the antiviral potency is found to be in the following decreasing order: adenine (β-isomer) > 6-chloropurine (β-isomer) > 6-chloropurine (α-isomer) > 2-NH2-6-Cl-purine (β-isomer) > guanine (β-isomer) > N6-methyladenine (α-isomer) > N6-methyladenine (β-isomer).The cytotoxicity was also determined in human PBM cells as well as Vero cells.None of the synthesized nucleosides was toxic up to 100 μ in PBM cells.

Structure-Activity Relationships of β-D-(2S,5R)- and α-D-(2S,5S)-1,3-oxathiolanyl Nucleosides as Potential Anti-HIV Agents

The β-D-(2S,5R)- and α-D-(2S,5S)-1,3-oxathiolanylpyrimidine and -purine nucleosides with natural nucleoside configuration were synthesized and evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells.The key intermediate 14, which was uti

SYNTHESIS OF 2',3'-DIDEOXY-D-ERYTHRO-HEX-2'-ENOPYRANOSYL NUCLEOSIDES FROM 5-AMINOURACILS AND 3,4,6-TRI-O-ACETYL-D-GLUCAL

Condensation of silylated N,N-disubstituted aminouracils (4) and 3,4,6-tri-O-acetyl-D-glucal (3) in the presence of TMS triflate as catalyst gave anomeric mixtures of 2',3'-dideoxy-D-erythro-hex-2'-enopyranosylnucleosides (5) and (6).The pure β- and α-ano