146797-19-5

Basic information

• Product Name: 1-(2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamine
• Synonyms: 1-(2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamine
• CAS NO: 146797-19-5
• Molecular Weight: 261.751
• Mol File: 146797-19-5.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamine(146797-19-5)
• EPA Substance Registry System: 1-(2-(4-chlorophenoxy)phenyl)-N,N-dimethylmethanamine(146797-19-5)

Safety Data

• Hazardous Substances Data: 146797-19-5(Hazardous Substances Data)

Upstream product

• 106-48-9 4-chloro-phenol 
• 129636-11-9 N,N-dimethyl-1-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)methanamine 
• 124-40-3 dimethyl amine 
• 111826-11-0 2-(4-chlorophenoxy)benzaldehyde 

Relevant articles and documents

Synthesis of Biaryl Ethers by the Copper-Catalyzed Chan-Evans-Lam Etherification from Benzylic Amine Boronate Esters

The copper-catalyzed etherification of ortho-borylated benzylic amines with phenols has been achieved to provide biaryl ethers that are prevalent in biologically active compounds. A variety of substitution patterns on the aryl boronate ester and the phenol are tolerated under the reaction conditions, providing moderate to high yields. A competition reaction between phenol and aniline revealed condition-dependent selectivity in which the phenol could be highly favored over the aniline.

1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity

A novel series of 1-(2-phenoxyphenyl)methanamines is disclosed, which possess selective dual 5-HT and NA reuptake pharmacology. Analogues with good human in vitro metabolic stability, hERG selectivity and passive membrane permeability were identified.