146864-18-8

Basic information

• Product Name: 4-chloromethyl-1,3,2-dioxathiolane 2-oxide
• CAS NO: 146864-18-8
• Molecular Weight: 156.59
• Mol File: 146864-18-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-chloromethyl-1,3,2-dioxathiolane 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloromethyl-1,3,2-dioxathiolane 2-oxide(146864-18-8)
• EPA Substance Registry System: 4-chloromethyl-1,3,2-dioxathiolane 2-oxide(146864-18-8)

Safety Data

• Hazardous Substances Data: 146864-18-8(Hazardous Substances Data)

Upstream product

• 96-24-2 3-monochloro-1,2-propanediol 
• 56-81-5 glycerol 
• 7719-09-7 thionyl chloride 
• 556-52-5 oxiranyl-methanol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 115798-86-2 5-o-tolyloxy-[1,3,2]dioxathiane-2-oxide 
• 109821-98-9 4-o-tolyloxymethyl-[1,3,2]dioxathiolane-2-oxide 
• 82019-13-4 4-phenoxymethyl-1,3,2-dioxathiolane 2-oxide 
• 114097-31-3 5-phenoxy-[1,3,2]dioxathiane-2-oxide 
• 623-81-4 diethyl sulphite 
• 538-43-2 3-phenoxy-1,2-propanediol 
• 556-52-5 oxiranyl-methanol 
• 84367-31-7 (R)-γ-chloro-β-hydroxybutyronitrile 

Relevant articles and documents

Chemo- and Regioselective Functionalization of Polyols through Catalytic C(sp3)-C(sp3) Kumada-Type Coupling of Cyclic Sulfate Esters

This contribution describes a copper-catalyzed, C(sp3)-C(sp3) cross-coupling reaction of cyclic sulfate esters, a distinct class of electrophilic derivatives of polyols, with alkyl Grignard reagents to afford functionalized alcohol products in good yields. The method is operationally simple and highlights the potential of cyclic sulfate esters as highly reactive substrates in catalytic, chemoselective polyol transformations.

Reactions of 4-chloromethyl-1,3,2-dioxathiolane 2-oxides with sodium phenoxide. A reinvestigation

The reactions of 4-chloromethyl-1,3,2-dioxathiolane 2-oxides with PhONa in EtOH are accompanied by ring opening under the action of the ethoxide ion rather than leading to a rearrangement of the starting molecule as has been assumed previously. Under conditions precluding competition with other nucleophiles, the phenoxide anion smoothly replaces the chlorine atom in chloromethyl-substituted cyclic sulfites.