146879-02-9

Basic information

• Product Name: N-(tert-butoxycarbonyl)-τ-methyl-L-histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
• Synonyms: N-(tert-butoxycarbonyl)-τ-methyl-L-histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane
• CAS NO: 146879-02-9
• Molecular Weight: 494.675
• Mol File: 146879-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(tert-butoxycarbonyl)-τ-methyl-L-histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butoxycarbonyl)-τ-methyl-L-histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane(146879-02-9)
• EPA Substance Registry System: N-(tert-butoxycarbonyl)-τ-methyl-L-histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane(146879-02-9)

Safety Data

• Hazardous Substances Data: 146879-02-9(Hazardous Substances Data)

Upstream product

• 104882-10-2 (2S,3R,4S)-2-[(tert-butyloxycarbonyl)amino]-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 122621-77-6 (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane 
• 61070-20-0 N^α-(tert-butoxycarbony1)- N^τ-methyl-L-histidine 

Relevant articles and documents

Studies directed toward the design of orally active renin inhibitors. 1. Some factors influencing the absorption of small peptides

A systematic evaluation of structure-absorption relationships using a high throughput intraduodenal rat screening model has led to the delineation of a set of structural parameters that appear to govern bioavailability in a series of peptide-based renin inhibitors. Optimum structures, exemplified by 25 and 41, incorporated a single, solubilizing substituent at the C- or N- terminus combined with a lipophilic P2-site residue. Both inhibitors gave unprecedented plasma drug levels upon intraduodenal administration to monkeys, and the calculated bioavailability for 41 (14 ± 4%) is the highest reported for any peptidic renin inhibitor.