146918-97-0 Usage
Uses
Used in Pharmaceutical Industry:
(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine is used as a nucleoside analog for the development of antiviral and anticancer drugs. Its unique chemical structure allows it to target specific viral and cancer cells, inhibiting their growth and replication.
Used in Chemical and Biological Research:
(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine is used as a stable isotope-labeled compound for chemical and biological research. The presence of deuterium and specific chemical modifications makes it a valuable tool for studying the structure, function, and dynamics of biomolecules and their interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 146918-97-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,9,1 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 146918-97:
(8*1)+(7*4)+(6*6)+(5*9)+(4*1)+(3*8)+(2*9)+(1*7)=170
170 % 10 = 0
So 146918-97-0 is a valid CAS Registry Number.
146918-97-0Relevant academic research and scientific papers
Syntheses and conformational studies on AZT and its deuterated analogues
Gurjar,Kunwar,Reddy,Islam,Lalitha,Jagannadh,Rama Rao
, p. 4373 - 4382 (2007/10/02)
The NMR spectrum of 3′-azido-3′-deoxythymidine (AZT) in aqueous solution provides sum of some of the proton-proton coupling constants. This limitation precludes the determination of the pseudorotational parameters of the sugar ring. Selective deuteration alleviates this problem. The synthesis of 2′-deutero and 3′-deutero- AZT have been described for the first time starting from D-xylose and β-thymidine respectively. NMR study of these analogues in aqueous solutions shows that almost equal amount of C-2′-endo and C-3′-endo species exist in equilibrium.
