1469293-95-5Relevant academic research and scientific papers
Synthesis and biological evaluation of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives as potential anticancer agents
Chavva,Pillalamarri,Banda,Gautham,Gaddamedi,Yedla,Kumar,Banda
, p. 5893 - 5895 (2013/10/22)
A series of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives 5, 6 and 7 were prepared starting from 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 3 via selective N-alkylation, followed by reaction with different primary aliphatic amines, cyclic secondary amines or l-amino acids under different set of conditions. All the synthesized compounds 5, 6 and 7 were screened for anticancer activity against four cancer cell lines such as A549 - Lung cancer (CCL-185), MCF7 - Breast cancer (HTB-22), DU145 - Prostate cancer (HTB-81) and HeLa - Cervical cancer (CCL-2). The compounds 5i and 6e are found to have promising bioactivity at micro molar concentration.
