146943-27-3

Upstream product

• 65874-27-3 4-(tert-butoxycarbonyl)benzaldehyde 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 619-58-9 4-iodobenzoic acid 
• 120363-13-5 tert-butyl 4-iodobenzoate 
• 292638-85-8 acrylic acid methyl ester 
• 88641-55-8 tetrabutylammonium chloride monohydrate 

Downstream Products

• 389625-37-0 tert-butyl 4-(1-ethyl-3-methoxy-3-oxopropyl)benzoate 
• 389625-38-1 tert-butyl 4-[1-(2-methoxy-2-oxoethyl)-2-propenyl]benzoate 
• 389625-36-9 tert-butyl 4-(3-methoxy-1-methyl-3-oxopropyl)benzoate 
• 126931-31-5 methyl 3-<4-(tert-butoxycarbonyl)phenyl>propanoate 
• 86208-18-6 3-<4-(tert-butoxycarbonyl)phenyl>propionic acid 
• 146943-43-3 N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid diethyl ester 
• 146943-41-1 4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-4,4-dimethoxy-butyl]-benzoic acid tert-butyl ester 
• 134373-06-1 4-[4,4-Dimethoxy-3-(2,4,6-triamino-pyrimidin-5-yl)-butyl]-benzoic acid tert-butyl ester 
• 137281-39-1 4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl )ethyl]benzoic acid 
• 134373-01-6 4-(4,4-Dicyano-3-dimethoxymethyl-butyl)-benzoic acid tert-butyl ester 
• 134373-00-5 tert-butyl 4-(4-methoxy-3-butenyl)benzoate 
• 134372-99-9 3-(4-<2,2-dimethylethyl>carboxyphenyl)-1-propanal 
• 126931-32-6 tert-Butyl 4-(3-hydroxy-1-propyl)benzoate 
• 150586-02-0 diethyl N-{4-[1-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-propenyl]benzoyl}-L-glutamate 

Relevant academic research and scientific papers

Integrin antagonists

This invention relates to novel heterocycles which are useful as antagonists of the αvβ3 integrin, the α2bβ3 integrin, and related cell surface adhesive protein receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.

Pyrrolo[2,3-d]pyrimidine thymidylate synthase inhibitors: Design and synthesis of one-carbon bridge derivatives

A series of novel pyrrolo[2,3-d]pyrimidine derivatives was designed and synthesized as thymidylate synthase (TS) inhibitors. Molecular design was performed on the human TS complex model built on the basis of the reported structure of TS-deoxyuridinemonoph

A Novel Synthetic Approach to Pyrrolopyrimidine Antifolates

A novel and efficient synthetic method for the synthesis of pyrrolopyrimidine antifolates is described.The key reaction of this method is the photo-initiated free radical addition of bromomalononitrile or ethyl bromocyanoacetate to an enol ether to afford the backbone skeleton of the targeted antifolate molecule.The key intermediates 3 or 4 are smoothly converted to the pyrrolopyrimidine antifolates 1 or 2 in three steps and in high overall yield.

Fused pyrimidines, their production and use

New fused pyrimidines of the general formula (I): STR1 wherein the ring A is a pyridine ring which may be hydrogenated or a benzene ring which may be hydrogenated, X is an amino group or a hydroxyl group, R1, R2, R3 and R