149325-57-5Relevant articles and documents
Pyrrolo[2,3-d]pyrimidine thymidylate synthase inhibitors: Design and synthesis of one-carbon bridge derivatives
Aso,Imai,Yukishige,Ootsu,Akimoto
, p. 1280 - 1287 (2007/10/03)
A series of novel pyrrolo[2,3-d]pyrimidine derivatives was designed and synthesized as thymidylate synthase (TS) inhibitors. Molecular design was performed on the human TS complex model built on the basis of the reported structure of TS-deoxyuridinemonoph
Novel 6-5 fused ring heterocycle antifolates with potent antitumor activity: Bridge modifications and heterocyclic benzoyl isosters of 2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidine antifolate
Kotake,Okauchi,Iijima,Yoshimatsu,Nomura
, p. 829 - 841 (2007/10/02)
Structural modifications of an extremely potent inhibitor of dihydrofolate reductase (DHFR) activity and tumor cell growth, N-[4-[3-(2,4-diamino-6,7-dihydro-5H-cyclopenta[d]pyrimidin-5-yl)propyl ]benzoyl]-L-glutamic acid (1), have led to the synthesis of