146948-95-0

Upstream product

• 146949-07-7 4-n-propylbenzenesulfonyl chloride 
• 75-64-9 tert-butylamine 

Downstream Products

• 154553-70-5 4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-5-propyl-biphenyl-2-sulfonic acid tert-butylamide 
• 154553-71-6 4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-ylmethyl)-5-propyl-biphenyl-2-sulfonic acid amide 
• 146948-96-1 2-(N-t-butylsulfamoyl)-5-n-propylphenylboronic acid 

Relevant academic research and scientific papers

L-162,389: A potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes

Simple modifications made to our potent angiotensin II AT1 selective clinical candidate MK-996 provided a compound with balanced binding affinity to both the AT1 and the AT2 receptor subtype. This compound, L-162,389 is or

SUBSTITUTED 1,2,4-TRIAZOLES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS

Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of the formula I are useful as angiotensin II antagonists. STR1

SUBSTITUTED PYRAZOLES, COMPOSITIONS AND USE

Substituted pyrazole compounds are angiotensin II antagonists and therefore useful in the treatment of hypertension, and related cardiovascular disorders and ocular hypertension. These compounds have the general formula I: STR1