L-162,389: A potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes

DOI: 10.1016/0960-894X(96)00017-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 307 - 310 (1996)

Update date:2022-08-05

Topics:

Authors:

Rivero Rivero

Kevin Kevin

Kivlighn

Zingaro Zingaro

Chang Chang

Greenlee

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Article abstract of DOI:10.1016/0960-894X(96)00017-0

Simple modifications made to our potent angiotensin II AT₁ selective clinical candidate MK-996 provided a compound with balanced binding affinity to both the AT₁ and the AT₂ receptor subtype. This compound, L-162,389 is or

Full text of DOI:10.1016/0960-894X(96)00017-0

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