146952-30-9

Basic information

• Product Name: Benzenemethanol, 2-(acetyloxy)-
• CAS NO: 146952-30-9
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Mol File: 146952-30-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 2-(acetyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 2-(acetyloxy)-(146952-30-9)
• EPA Substance Registry System: Benzenemethanol, 2-(acetyloxy)-(146952-30-9)

Safety Data

• Hazardous Substances Data: 146952-30-9(Hazardous Substances Data)

Usage

Chemical compound

Benzenemethanol, 2-(acetyloxy)-

Physical form

white, crystalline powder

Function

pain reliever, anti-inflammatory, fever reducer

Mechanism of action

inhibits production of certain chemicals causing pain and inflammation

Specific content

Active ingredient in aspirin
Widely used medication
Available over the counter
Used to treat headaches, muscle aches, arthritis, fevers

Potential side effects

stomach irritation, bleeding in some individuals

Upstream product

• 5663-67-2 2-acetoxybenzaldehyde 
• 90-01-7 salicylic alcohol 
• 75-36-5 acetyl chloride 
• 5538-51-2 O-acetylsalicyloyl chloride 
• 89-95-2 2-methyl-benzyl alcohol 
• 108-24-7 acetic anhydride 

Downstream Products

• 1118974-20-1 2-acetyloxybenzyl diethylphosphate 
• 15068-08-3 o-chloromethylphenyl acetate 

Relevant articles and documents

Nickel(II) Catalyzed Hydroboration: A Route to Selective Reduction of Aldehydes and N-Allylimines

A cationic [(iminophosphine)nickel(allyl)]+ complex was found to be sufficiently electrophilic to activate aldehydes and N-allylimines to undergo hydroboration with pinacolborane (HBpin) under mild reaction conditions. The catalyst displayed excellent selectivity toward aldehydes in the presence of ketones. A wide variety of functional groups were tolerated, including halogens, NO2, CN, OMe, and alkenes for both aldehydes and imines. Electron-rich substrates were found to be significantly more reactive than their electron poor counterparts, a feature that was correlated to their enhanced ability to coordinate to the Lewis acidic nickel center.

Homoleptic iron(II) and cobalt(II) bis(phosphoranimide) complexes for the selective hydrofunctionalization of unsaturated molecules

Low-coordinate homoleptic bulky M2(NPtBu3)4 (M = Fe (A), Co (B)) complexes were synthesized and characterized as dimeric structures by crystallographic studies. The iron complex A can catalyze the hydroboration reaction of aldehydes and ketones. The cobalt complex B outperformed its iron counterpart in hydrogenations of several typical alkenes and alkynes under mild conditions. Poisoning experiments indicate that the Co(ii)/HBpin catalytic system could be homogeneous.

Ruthenium Catalyzed Selective Hydroboration of Carbonyl Compounds

Using the [Ru(p-cymene)Cl2]2 (1) complex, catalytic hydroboration of aldehydes and ketones with pinacolborane under neat and mild conditions is reported. At rt, chemoselective hydroboration of aldehydes over the ketones is also attained. Mechanistic studies confirmed the immediate formation of monohydride bridged dinuclear complex [{(μ6-p-cymene)RuCl}2(μ-H-μ-Cl)] (1b) from the reaction of 1 with pinacolborane, which catalyzed the highly efficient hydroboration reactions. The catalytic cycle containing mononuclear Ru-H species and intramolecular 1,3-hydride transfer is postulated.