1469772-04-0

Basic information

• Product Name: 2,4,5-trichloro-6-(5-(3-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile
• Synonyms: 2,4,5-trichloro-6-(5-(3-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile
• CAS NO: 1469772-04-0
• Molecular Weight: 516.173
• Mol File: 1469772-04-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4,5-trichloro-6-(5-(3-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-trichloro-6-(5-(3-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile(1469772-04-0)
• EPA Substance Registry System: 2,4,5-trichloro-6-(5-(3-chlorophenylamino)-4-oxo-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile(1469772-04-0)

Safety Data

• Hazardous Substances Data: 1469772-04-0(Hazardous Substances Data)

Upstream product

• 865713-10-6 C₁₄H₉ClN₄O₃ 
• 1897-45-6 chlorothalonil 
• 915150-57-1 8-amino-5-(3-chlorophenylamino)quinazolin-4(3H)-one 
• 108-42-9 3-chloro-aniline 
• 400784-50-1 5-chloro-8-nitro-quinazolin-4(3H)-one 

Relevant articles and documents

Synthesis and antimicrobial activity of polyhalobenzonitrile quinazolin-4(3H)-one derivatives

A novel series of polyhalobenzonitrile quinazolin-4(3H)-one derivatives were synthesized and characterized by NMR, IR, MS, and HRMS spectra. All of the newly prepared compounds were screened for antimicrobial activities against four strains of bacteria (Gram-positive bacterial: Staphylococcus aureus and Bacillus cereus; Gram-negative bacterial: Escherichia coli and Pseudomonas aeruginosa) and one strain of fungi (Candida albicans). Among the synthesized compounds, 5-(dimethylamino)-8-(2,4,5-trichloro-isophthalonitrile) quinazolin-4(3H)-one (7k) exhibited significant activity towards Gram-positive bacterial, Gram-negative bacterial, and the fungi strains. The MIC (0.8-3.3 μg/mL) and MBC (2.6-7.8 μg/mL) for this compound were close to those of nofloxacin, chlorothalonil, and fluconazole, making it the most potent antimicrobial agents in the series.