147000-78-0

Basic information

• Product Name: tert-butyl 3-benzyl-2,2-dioxo-2lambda~6~-diazathiane-1-carboxylate
• Synonyms: tert-butyl 3-benzyl-2,2-dioxo-2lambda~6~-diazathiane-1-carboxylate;N'-Benzylsulphamide, N-BOC protected;tert-Butyl 3-benzyl-2,2-dioxodiazathiane-1-carboxylate, tert-Butyl (N-benzylsulphamoyl)carbamate, N-Benzyl-N'-(tert-butoxycarbonyl)sulphuric diamide
• CAS NO: 147000-78-0
• Molecular Formula: C₁₂H₁₈N₂O₄S
• Molecular Weight: 286.34732
• Mol File: 147000-78-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 106～108℃
• Appearance: /
• CAS DataBase Reference: tert-butyl 3-benzyl-2,2-dioxo-2lambda~6~-diazathiane-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-benzyl-2,2-dioxo-2lambda~6~-diazathiane-1-carboxylate(147000-78-0)
• EPA Substance Registry System: tert-butyl 3-benzyl-2,2-dioxo-2lambda~6~-diazathiane-1-carboxylate(147000-78-0)

Safety Data

• Hazardous Substances Data: 147000-78-0(Hazardous Substances Data)

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 100-46-9 benzylamine 
• 75-65-0 tert-butyl alcohol 
• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 
• 352275-00-4 (tert-butoxycarbonyl)-((4-(dimethyliminio)pyridin-1(4H)-yl)sulfonyl)amide 

Downstream Products

• 603132-74-7 N-benzyl-N'-bromoheptyl-N'-tert-butoxycarbonyl sulfamide 
• 603132-75-8 N-benzyl-N'-bromooctyl-N'-tert-butoxycarbonyl sulfamide 
• 603132-72-5 N-benzyl-N'-bromopentyl-N'-tert-butoxycarbonyl sulfamide 
• 603132-77-0 N-benzyl-N'-bromodecyl-N'-tert-butoxycarbonyl sulfamide 
• 603132-78-1 N-benzyl-N'-bromoundecyl-N'-tert-butoxycarbonyl sulfamide 
• 603132-71-4 N-benzyl-N'-bromobutyl-N'-tert-butoxycarbonyl sulfamide 
• 603132-69-0 N-benzyl-N'-bromoethyl-N'-tert-butoxycarbonyl sulfamide 
• 934978-64-0 N'-benzyl-N-{[5-(3-bromopropa-1,2-dienyl)-2,2-dimethyl-1,3-dioxan-5-yl]methyl}-N-(tert-butoxycarbonyl)sulfamide 

Relevant articles and documents

Simple, rapid, and clean condensation of sulfonamide and maleic anhydride derivatives: Synthesis of novel 1H- Pyrrole-2,5-diones under heterogeneous conditions

H6P2W18O62is used as an efficient catalyst for the synthesis of novel N-substituted sulfonyl maleimides (1H-Pyrrole-2,5-diones) via the condensation of sulfonamide and maleic anhydride derivatives. The Dawson heteropolyacid was used with a catalytic amount of 2?mmol% in acetonitrile at reflux. The reuse of H6P2W18O62as heterogeneous catalyst several times without decrease in their activity, short reaction times, easy isolation of desired products with good to excellent yields shows the advantages of this novel methodology.

SULFAMIDE LINKER, CONJUGATES THEREOF, AND METHODS OF PREPARATION

The present invention relates to a compound comprising an alpha-end and an omega-end, the compound comprising on the alpha-end a reactive group Qlcapable of reacting with a functional group F1present on a biomolecule and on the omega-end a target molecule, the compound further comprising a group according to formula (1) or a salt thereof: Said compound may also be referred to as a linker-conjugate. The invention also relates to a process for the preparation of a bioconjugate, the process comprising the step of reacting a reactive group Q1of a linker-conjugate according to the invention with a functional group F1of a biomolecule. The invention further relates to a bioconjugate obtainable by the process according to the invention. In a preferred embodiment, the invention concerns a process for the preparation of a bioconjugate via a cycloaddition, such as a (4+2)-cycloaddition (e.g. a Diels-Alder reaction) or a (3+2)-cycloaddition (e.g. a 1,3-dipolar cycloaddition).

Convenient Synthesis of Novel N -Acylsulfonamides Containing Phosphonate Moiety

The present study describes a convenient method for the synthesis of new N-acylsulfonamides containing phosphonate moiety. The N-acylsulfonamides were prepared starting from chlorosulfonyl isocyanate (CSI) in four steps (carbamoylation, sulfamoylation, deprotection, and acylation). Trimethylphosphite has been used to introduce the phosphonate moiety into N-acylsulfonamides via Arbuzov reaction. GRAPHICAL ABSTRACT