14702-94-4

Basic information

• Product Name: 3-Benzyl-2-cyan-buten-⁽²⁾-saeure-⁽¹⁾-methylester
• CAS NO: 14702-94-4
• Molecular Weight: 215.252
• Mol File: 14702-94-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Benzyl-2-cyan-buten-⁽²⁾-saeure-⁽¹⁾-methylester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzyl-2-cyan-buten-⁽²⁾-saeure-⁽¹⁾-methylester(14702-94-4)
• EPA Substance Registry System: 3-Benzyl-2-cyan-buten-⁽²⁾-saeure-⁽¹⁾-methylester(14702-94-4)

Safety Data

• Hazardous Substances Data: 14702-94-4(Hazardous Substances Data)

Upstream product

• 103-79-7 1-phenyl-acetone 
• 105-34-0 methyl 2-cyanoacetate 

Downstream Products

• 378220-97-4 methyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 
• 91641-68-8 Monoamid der α-Methyl-α-benzyl-bernsteinsaeure 
• 91391-88-7 α-Methyl-α-benzyl-bernsteinsaeure-dinitril 
• 92041-84-4 α-Methyl-α-benzyl-bernsteinsaeure-methylester-amid 
• 32980-47-5 2-benzyl-2-methyl-succinic acid 
• 29840-32-2 3-Benzyl-2,3-dicyan-buttersaeure-methylester 

Relevant articles and documents

Substituted 2-Aminothiopen-derivatives: A potential new class of GluR6-Antagonists

In the course of search for new therapeutic agents against epilepsy new inhibitors for the kainate receptor subtypes GluR5 and GluR6 were synthesized. We were able to synthesize new substituted thieno[2,3-d]pyrimidines 3a,b, 4a,b, 5a,b as well as thiophene-3-carboxamides 2a-d and a multitude of substituted 4-methyl-5-phenylthiophene-3-carboxylic acids. All compounds described herein were tested for their antagonistic effect towards the kainate receptor subtypes GluR5 and GluR6. The highest activity was observed for ethyl 2-amino-4-methyl-5-phenylthiophene-3-carboxylate 1c with an IC50 = 0.75 μM at the GluR6 receptor.