32980-47-5

Upstream product

• 1250909-61-5 ethyl (R)-(+)-3-benzyl-3-methyl-4-nitrobutanoate 
• 247588-14-3 (S)-methyl 2-benzyl-2-methyl-3-iodopropanoate 
• 247588-13-2 (R)-methyl 2-benzyl-2-methyl-3-hydroxypropanoate 
• 98061-14-4 (R)-2-benzyl-2-methylpropanedioic acid monomethyl ester 
• 247588-15-4 (R)-methyl 2-benzyl-2-methyl-3-cyanopropanoate 
• 29840-37-7 α,β-Dicyan-β-benzyl-buttersaeureaethylester 
• 29840-32-2 3-Benzyl-2,3-dicyan-buttersaeure-methylester 
• 7148-59-6 2-cyano-3-methyl-4-phenyl-crotonic acid ethyl ester 
• 14702-94-4 3-Benzyl-2-cyan-buten-⁽²⁾-saeure-⁽¹⁾-methylester 
• 70836-95-2 methyl-3-phenyl-propionic acid tert-butyl ester 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 32980-27-1 1-Ethyl 4-hydrogen 2-methylbutanedioate 
• 100-44-7 benzyl chloride 
• 91391-88-7 α-Methyl-α-benzyl-bernsteinsaeure-dinitril 

Downstream Products

• 88613-45-0 α-Methyl-α-(4-nitro-benzyl)-bernsteinsaeure 
• 92865-22-0 2-Benzyl-2-methyl-bernsteinsaeure-dimethylester 
• 97025-08-6 2-Methyl-2-benzyl-bernsteinsaeure-monomethylester-⁽⁴⁾ 

Relevant academic research and scientific papers

Esterase-mediated synthesis of optically active GABA analogues containing a stereogenic all-carbon quaternary carbon atom

Esterase from Horse Liver (HLAP) was able to hydrolyze a series of linear and cyclic β,β-dialkyl-γ-nitroesters, in spite of the well-known reluctance of hydrolytic enzymes to recognize and transform hindered substrates, such as those possessing a stereoge

2-Benzyl-2-methylsuccinic acid as inhibitor for carboxypeptidase A. synthesis and evaluation

Recently, Asante-Appiah et al. (Asante-Appiah, E.; Seetharaman, J.; Sicheri, F.; Yang, D. S.-C.; Chan, W. W.-C. Biochemistry 1997, 36, 8710-8715) reported that 2-ethyl-2-methylsuccinic acid is a highly potent inhibitor for carboxypeptidase A (CPA), a prototypic zinc protease. The X-ray crystal structure of the complex of the enzyme formed with 2-ethyl-2-methylsuccinic acid revealed that at the active site of CPA there is present a small cavity which accommodates the methyl group of the inhibitor. These investigators postulated that incorporation of a methyl group at the α-position to the carboxylate of existing inhibitors of CPA would improve the inhibitory potency. We have synthesized racemic and optically active 2-benzyl-2-methylsuccinic acids and evaluated their inhibitory activities for CPA to find the K(i) values to be 0.28, 0.15, and 17μM for racemic form, (R)-, and (S)-enantiomer, respectively. Contrary to the expectation, the effect on the binding affinity by the incorporation of the methyl group is minimal. The validity of the proposition that the small cavity may be utilized for the improvement of the inhibitory potency appears questionable. Copyright (C) 1999 Elsevier Science Ltd.

CARBOXYALKYL TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE

The present invention relates to compounds of the formula STR1 wherein B 1 and B 2 are each independently hydrogen; hydroxy;--OR 2 wherein R 2 is a C 1-C 4 alkyl or an Ar--Y group wherein Ar is aryl and Y is a hydrogen or C 1-C 4 alkyl; or, where B 1 and