1470408-05-9

Basic information

• Product Name: 3-(1-isopropyl-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione
• Synonyms: 3-(1-isopropyl-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione
• CAS NO: 1470408-05-9
• Molecular Weight: 574.682
• Mol File: 1470408-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(1-isopropyl-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-isopropyl-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione(1470408-05-9)
• EPA Substance Registry System: 3-(1-isopropyl-1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione(1470408-05-9)

Safety Data

• Hazardous Substances Data: 1470408-05-9(Hazardous Substances Data)

Upstream product

• 959418-00-9 4-chloro-3-(1H-indol-3-yl)-1-phenyl-1H-pyrrole-2,5-dione 
• 1470408-01-5 3-(1H-indol-3-yl)-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1-phenyl-1H-pyrrole-2,5-dione 
• 75-26-3 isopropyl bromide 
• 1470408-00-4 3-(1-(tert-butyloxycarbonyl)-1H-indol-3-yl)-1-phenyl-4-(1-(3-morpholinopropyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)-1H-pyrrole-2,5-dione 
• 1178564-33-4 3-(tributylstannanyl)-1H-pyrazolo[3,4-b]pyridine 
• 1470407-99-8 3-(1-(tert-butyloxycarbonyl)-1H-indol-3-yl)-1-phenyl-4-(1H-pyrazolo[3,4-b]pyridine-3-yl)-1H-pyrrole-2,5-dione 
• 117007-52-0 3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 271-73-8 1H-Pyrazolo[3,4-b]pyridine 
• 63682-46-2 C₆H₄N₅⁽¹⁺⁾*BF₄^(1-) 
• 6752-16-5 1H-pyrazolo[3,4-b]pyridin-3-amine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Relevant articles and documents

Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors

A series of 7-azaindazolyl-indolyl-maleimides were designed, synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited potent activity against GSK-3β. Among them, compounds 17a, 17b, 17g, 17i, 29a and 30 significantly reduced Aβ-induced Tau hyperphosphorylation, showin;g the inhibition of GSK-3β at the cell level. Preliminary structure-activity relationships were discussed based on the experimental data obtained.