147081-59-2

Basic information

• Product Name: 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI)
• Synonyms: 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI);(3S)-3-(Methylamino)-1-Pyrrolidinecarboxylicacid 1,1-imethylethyl ester;tert-Butyl-(3S)-3-(methylamino)pyrrolidine-1-carboxylate;1-N-Boc-3-(S)-(Methylamino) pyrrolidine;1-N-Boc-(S)-(methylamino)-pyrrolidine;1-Pyrrolidinecarboxylicacid,3-(MethylaMino)-,1,1-diMethylethylester,(3S)-;(3S)-3-(Methylamino)-1-pyrrolidinecarboxylic acid tert-butyl ester;tert-butyl (S)-3-(methylamino)pyrrolidine-1-carboxylate
• CAS NO: 147081-59-2
• Molecular Formula: C₁₀H₂₀N₂O₂
• Molecular Weight: 200.28
• Product Categories: AMINOACID
• Mol File: 147081-59-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 269℃
• Flash Point: 117℃
• Appearance: /
• Density: 1.03
• Vapor Pressure: 0.00725mmHg at 25°C
• Refractive Index: 1.485
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.02±0.20(Predicted)
• CAS DataBase Reference: 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI)(147081-59-2)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI)(147081-59-2)

Safety Data

• Hazardous Substances Data: 147081-59-2(Hazardous Substances Data)

Usage

General Description

"1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI)" is a complex chemical compound with various potential applications in biochemical research and pharmaceutical development. 1-Pyrrolidinecarboxylicacid,3-(methylamino)-,1,1-dimethylethylester,(3S)-(9CI) is characterized by its pyrrolidine ring, a potential acid moiety, and a methylamine group, all of which could influence its reactivity as well as its physicochemical properties. Its N,N-dimethylethyl ester group could make it more lipophilic, influencing its solubility and absorption. The (3S)- stereoisomer indicates it is one of the two possible spatial arrangements of the molecule, which could significantly impact its interactions with biological molecules. The compound is listed in the ninth collective index (9CI) of organic compounds, indicating its recognition and documentation in the field of organic chemistry.

InChI:InChI=1/C10H20N2O2/c1-10(2,3)14-9(13)12-6-5-8(7-12)11-4/h8,11H,5-7H2,1-4H3/t8-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 139015-32-0 (3S)-(-)-3-(methylamino)pyrrolidine 
• 427885-95-8 tert-butyl (3S)-3-[(2-nitrophenyl)sulfonylamino]pyrrolidine-1-carboxylate 
• 427885-96-9 tert-butyl (3S)-3-[methyl-(2-nitrophenyl)sulfonyl-amino]pyrrolidine-1-carboxylate 
• 147081-44-5 (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 127423-61-4 tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate 
• 74-89-5 methylamine 
• 892390-43-1 tert-butyl (3S)-3-(formylamino)pyrrolidine-1-carboxylate 

Downstream Products

• 852329-46-5 ((S)-1-Boc-pyrrolidin-3-yl)-methyl-carbamic acid 4-nitrophenyl ester 

Relevant articles and documents

(S)-N-methyl-N-(pyrrolidin-3-yl)acetamide dihydrochloride and synthesis method therefor

The invention discloses (S)-N-methyl-N-(pyrrolidin-3-yl)acetamide dihydrochloride and a synthesis method therefor and belongs to the technical field of organic chemical synthesis. The synthesis methodcomprises the following procedures: subjecting (R)-3-pyridonyl-1-tert-butyl carboxylate, which serves as a raw material, to reactions of four steps, i.e., methanesulfonate synthesis, methyl amination, acetyl loading and tert-butyloxycarbonyl removing salt forming, thereby obtaining the (S)-N-methyl-N-(pyrrolidin-3-yl)acetamide dihydrochloride. The synthesis method for the (S)-N-methyl-N-(pyrrolidin-3-yl)acetamide dihydrochloride, provided by the invention, is safe, convenient and economical, the obtained (S)-N-methyl-N-(pyrrolidin-3-yl)acetamide dihydrochloride is stable in performance and can be conveniently stored and transported.

CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY

The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

NOVEL COMPOUNDS

A compound of Formula (I) and pharmaceutically and/or veterinarily acceptable derivatives thereof, wherein: R1 is H, C1-6alkyl, - C(A)D, C3-8cycloalkyl, aryl, het, aryl-C1-4alkyl or het-C1-4/sub