147088-91-3

Upstream product

• 1963-43-5 (4-methoxyphenyl)(1H-pyrrol-2-yl)methanone 
• 100-07-2 4-methoxy-benzoyl chloride 
• 91917-50-9 (4-methoxyphenyl)(1H-pyrrol-3-yl)methanone 
• 147089-08-5 (4-Methoxy-phenyl)-{5-[2-(4-methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrol-3-yl}-methanone 
• 147089-44-9 (4-Methoxy-phenyl)-{4-[2-(4-methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrol-2-yl}-methanone 
• 147089-55-2 2,4-Bis-[2-(4-methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole 
• 91917-45-2 (1-Benzenesulfonyl-1H-pyrrol-3-yl)-(4-methoxy-phenyl)-methanone 
• 147089-26-7 3-[2-(4-Methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole 
• 147089-18-7 1-Benzenesulfonyl-3-[2-(4-methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-1H-pyrrole 
• 147089-34-7 4-[2-(4-Methoxy-phenyl)-benzo[1,3]dithiol-2-yl]-2-[2-(4-methoxy-phenyl)-benzo[1,3]oxathiol-2-yl]-1H-pyrrole 

Relevant academic research and scientific papers

Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides

Starting from the known inhibitory activity of (3-benzoylpyrrol-1-yl)acetic acid (I) and (2-benzoylpyrrol-1-yl)acetic acid (II), a series of 3-aroyl and 2,4-bis-aroyl derivatives (54-75) were synthesized and tested for inhibition of aldose reductase, an e

General Methods for Synthesizing 2,4-Diacylpyrroles and their Precursors Containing One or Two Masked Acyl Groups

A thorough study of the synthesis of 2,4-diacylpyrroles by direct acylation of pyrrole and 2- and 3-acylpyrroles is reported.Among these, Friedel-Crafts acylation of 3-acylpyrroles is the most general and advantageous method because it utilises easily accessible starting materials.In addition it is always regiospecific and readily provides 2,4-diacylpyrroles containing identical or different acyl groups in very high yields (81-100percent) under mild conditions, Alternative procedures concern the synthesis of precursors of 2,4-diacylpyrroles containing one or two acyl groups masked by a 1,3-benzodithiolyl or 1,3-benzoxathiolyl group and subsequent hydrolysis with HgO-35percent aq.HBF4-Me2SO.Overall yields are always good (52-60percent).Indirect acylation constitutes a secure complement to direct acylation when it is necessary to operate in the presence of protected acyl groups.