1471178-23-0

Basic information

• Product Name: 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid
• Synonyms: 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid
• CAS NO: 1471178-23-0
• Molecular Weight: 372.303
• Mol File: 1471178-23-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid(1471178-23-0)
• EPA Substance Registry System: 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid(1471178-23-0)

Safety Data

• Hazardous Substances Data: 1471178-23-0(Hazardous Substances Data)

Upstream product

• 370-35-4 diethyl 2-({[3-(trifluoromethyl)phenyl]amino}methylidene)propanedioate 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 98-16-8 3-trifluoromethylaniline 
• 574-92-5 4-hydroxy-7-(trifluoromethyl)-3-quinolinecarboxylic acid 
• 17201-43-3 4-cyanobenzyl bromide 
• 1471177-97-5 ethyl 1-(4-cyanobenzyl)-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate 
• 23851-84-5 4-hydroxy-8-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 
• 391-02-6 4-hydroxy-7-trifluoromethyl-quinoline-3-carboxylic acid ethyl ester 
• 23779-94-4 2-[(2-trifluoromethylphenylamino)methylene]malonic acid diethyl ester 

Relevant articles and documents

Design and regioselective synthesis of trifluoromethylquinolone derivatives as potent antimicrobial agents

Three series of new trifluoromethyl substituted quinolone derivatives were synthesized (4a-f, 6a-f and 8a-f) from corresponding substituted anilines by multi-step reactions. The regioselective alkylation with different alkyl halides were carried out by approaching two different routes to get the final products in good yield. Newly synthesized compounds were characterized by spectral study and also by C, H, N analyses. Three dimensional structure of 2b and 4b were also confirmed by single crystal X-ray studies. The final compounds (4a-f, 6a-f and 8a-f) were screened for their in-vitro antibacterial and antifungal activity by well plate method (zone of inhibition). The results revealed that, compounds 4a, 6b, 6c and 8e showed significant antibacterial activity as compared to the standard drug Ciprofloxacin. The compound 8a was found to be a potent antifungal agent.